Evidence map›Paper›PMID 33173002›Full record

ArticlemBio2020

The Transcription Factor SomA Synchronously Regulates Biofilm Formation and Cell Wall Homeostasis in

Yuan Chen, Francois Le Mauff, Yan Wang, Ruiyang Lu, Donald C Sheppard, Ling Lu, Shizhu Zhang

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  4. TheJournal of fungi (Basel, Switzerland) · 2025
    Article
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  6. Recent developments inMicrobiology and molecular biology reviews : MMBR · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Yuan ChenJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Francois Le MauffDepartments of Medicine and of Microbiology and Immunology, McGill University, Montréal, Canada.
Yan WangJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Ruiyang LuJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
Donald C SheppardDepartments of Medicine and of Microbiology and Immunology, McGill University, Montréal, Canada.
Ling LuJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China linglu@njnu.edu.cn szzhang@njnu.edu.cn.ORCID 0000-0002-2891-7326
Shizhu ZhangJiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Microbiology, College of Life Sciences, Nanjing Normal University, Nanjing, China linglu@njnu.edu.cn szzhang@njnu.edu.cn.ORCID 0000-0002-0283-3714
Nanjing Normal University · CNMcGill University Health Centre · CA

Funding

CIHR 123306CIHR 81361CIHR FDN-159902
6 · The paper itself

Abstract

Polysaccharides are key components of both the fungal cell wall and biofilm matrix. Despite having distinct assembly and regulation pathways, matrix exopolysaccharide and cell wall polysaccharides share common substrates and intermediates in their biosynthetic pathways. It is not clear, however, if the biosynthetic pathways governing the production of these polysaccharides are cooperatively regulated. Here, we demonstrate that cell wall stress promotes production of the exopolysaccharide galactosaminogalactan (GAG)-depend biofilm formation in the major fungal pathogen of humans

Indexed as

BiofilmsAspergillosisAspergillus fumigatusCell WallFungal ProteinsGene Expression Regulation, FungalGlucoseHomeostasisHumansPolysaccharidesPromoter Regions, GeneticTranscription FactorsFungal ProteinsgalactosaminogalactanGlucosePolysaccharidesTranscription FactorsAspergillus fumigatusbiofilmcell wallfungal pathogenpolysaccharides

Identifiers

PMID33173002
PMCPMC7667024
OpenAlexW3102300687

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.