Evidence map›Paper›PMID 33173001›Full record

ArticlemBio2020

Plasmodium berghei K13 Mutations Mediate

Nelson V Simwela, Barbara H Stokes, Dana Aghabi, Matt Bogyo, David A Fidock, Andrew P Waters

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Ubiquitin-proteasome system inFrontiers in medicine · 2024
    Pooled it
  2. A review on molecular markers ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025
    Review
  3. Review
  4. Review
  5. The essential genome ofScience (New York, N.Y.) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. New targets for antimalarial drug discovery.Current opinion in microbiology · 2022
    Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Nelson V SimwelaInstitute of Infection, Immunity & Inflammation, Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom.ORCID 0000-0002-4734-0518
Barbara H StokesDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA.ORCID 0000-0001-9519-487X
Dana AghabiInstitute of Infection, Immunity & Inflammation, Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom.
Matt BogyoDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, California, USA.ORCID 0000-0003-3753-4412
David A FidockDepartment of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, USA df2260@cumc.columbia.edu Andy.Waters@glasgow.ac.uk.ORCID 0000-0001-6753-8938
Andrew P WatersInstitute of Infection, Immunity & Inflammation, Wellcome Centre for Integrative Parasitology, University of Glasgow, Glasgow, United Kingdom df2260@cumc.columbia.edu Andy.Waters@glasgow.ac.uk.ORCID 0000-0001-8900-2982
Wellcome Centre for Molecular Parasitology · GBColumbia University Irving Medical Center · USStanford University · US

Funding

Defining P. falciparum resistance to artemisinin-based combination therapiesR01AI109023 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FIDOCK, DAVID A · 2014 to 2025
$4.4M
Columbia University Graduate Training Program in Microbiology and ImmunologyT32AI106711 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Nicholas Arpaia, Uttiya Basu · 2014 to 2026
$2.1M
Parasite-specific proteasome inhibitors to combat multi-drug resistant malariaR33AI127581 · NIAID · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2019 to 2021
$1.4M
Parasite-specific proteasome inhibitors to combat multi-drug resistant malariaR21AI127581 · NIAID · STANFORD UNIVERSITY · PI BOGYO, MATTHEW · 2017 to 2018
$447k
NIAID NIH HHS R01 AI109023NIAID NIH HHS R21 AI127581NIAID NIH HHS R33 AI127581NIAID NIH HHS T32 AI106711Wellcome TrustWellcome Trust 083811/Z/07/ZWellcome Trust 104111/Z/14/ZWellcome Trust 107046/Z/15/Z
6 · The paper itself

Abstract

The recent emergence of

Indexed as

Drug ResistanceAnimalsAntimalarialsArtemisininsFemaleHumansMalariaMiceMutationPlasmodium bergheiPlasmodium falciparumProteasome Endopeptidase ComplexProteasome InhibitorsProtozoan ProteinsAntimalarialsartemisininArtemisininsProteasome Endopeptidase ComplexProteasome InhibitorsProtozoan Proteinsartemisinin resistancegene editingK13malariaparasite clearance timesPlasmodium bergheiPlasmodium falciparumproteasomering-stage survival assayssynergy

Identifiers

PMID33173001
PMCPMC7667033
OpenAlexW3100108856

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.