Evidence map›Paper›PMID 33173000›Full record

ArticlemBio2020

Identification of Zinc-Dependent Mechanisms Used by Group B

Lindsey R Burcham, Yoann Le Breton, Jana N Radin, Brady L Spencer, Liwen Deng, Aurélia Hiron, Monica R Ransom, Jéssica da C Mendonça, Ashton T Belew, Najib M El-Sayed and 3 more

Abstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Metal uptake systems underpinInfection and immunity · 2026
    Article
  5. The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  6. Article
  7. A murine model of adult gastrointestinal colonization by Group BbioRxiv : the preprint server for biology · 2025
    Article
  8. Review
  9. Article
  10. Identification of glyoxalase A in group BInfection and immunity · 2025
    Article
  11. Article
  12. Identification of Glyoxalase A in Group BbioRxiv : the preprint server for biology · 2024
    Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Review
  18. The role of transcriptional regulators in metal ion homeostasis ofFrontiers in cellular and infection microbiology · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lindsey R BurchamDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.ORCID 0000-0002-5182-796X
Yoann Le Breton *Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Jana N Radin *Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Brady L SpencerDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Liwen DengDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Aurélia HironUniversité de Tours, INRAE, ISP, Tours, France.
Monica R RansomDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jéssica da C MendonçaDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA.
Ashton T BelewCell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.
Najib M El-SayedCell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.ORCID 0000-0001-7970-3312
Kevin S McIver *Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, USA.ORCID 0000-0002-4769-4463
Thomas E Kehl-Fie *Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0001-8234-1113
Kelly S DoranDepartment of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, USA kelly.doran@cuanschutz.edu.ORCID 0000-0003-4232-6837

Funding

TRAINING PROGRAM IN IMMUNOLOGYT32AI007405 · NIAID · UNIVERSITY OF COLORADO DENVER · PI Laurel L Lenz, Raul Martin Torres · 1991 to 2026
$10.5M
PRD-Containing Virulence Regulators of Pathogenic StreptococciR01AI047928 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI MCIVER, KEVIN S. · 2001 to 2023
$6.5M
Modulation of Blood-Brain Barrier Defense and Dysfunction during Bacterial MeningitisR01NS116716 · NINDS · UNIVERSITY OF COLORADO DENVER · PI DORAN, KELLY S · 2020 to 2024
$1.9M
Overcoming nutritional immunity: Staphylococcal adaptation to host-imposed manganese and zinc starvationR01AI118880 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2016 to 2020
$1.9M
The Role of Cas9 in Group B Streptococcal Colonization and DiseaseF32AI143203 · NIAID · UNIVERSITY OF COLORADO DENVER · PI SPENCER, BRADY L · 2020 to 2021
$134k
NIAID NIH HHS F32 AI143203NIAID NIH HHS R01 AI047928NIAID NIH HHS R01 AI118880NIAID NIH HHS T32 AI007405NINDS NIH HHS R01 NS116716
6 · The paper itself

Abstract

Nutritional immunity is an elegant host mechanism used to starve invading pathogens of necessary nutrient metals. Calprotectin, a metal-binding protein, is produced abundantly by neutrophils and is found in high concentrations within inflammatory sites during infection. Group B

Indexed as

AnimalsBacterial ProteinsFemaleHumansLeukocyte L1 Antigen ComplexMeningitis, BacterialMiceMice, Inbred C57BLMice, KnockoutNeutrophilsStreptococcal InfectionsStreptococcus agalactiaeVirulenceZincBacterial ProteinsLeukocyte L1 Antigen ComplexZinccalprotectinGBSmeningitisnutritional immunityzinc

Identifiers

PMID33173000
PMCPMC7667036

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.