Evidence map›Paper›PMID 33172997›Full record

ArticlemBio2020

Impact of Nuclear Export Pathway on Cytoplasmic HIV-1 RNA Transport Mechanism and Distribution.

Jianbo Chen, Chijioke Umunnakwe, David Q Sun, Olga A Nikolaitchik, Vinay K Pathak, Ben Berkhout, Atze T Das, Wei-Shau Hu

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. Transcription start site heterogeneity controls MDA5 sensing of unspliced HIV-1 RNAs.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency.Frontiers in cellular and infection microbiology · 2022
    Review
  9. Review
  10. 5'-Cap sequestration is an essential determinant of HIV-1 genome packaging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jianbo ChenViral Recombination Section, HIV Dynamics and Replication Progam, National Cancer Institute, Frederick, Maryland, USA chenjia@mail.nih.gov Wei-Shau.Hu@nih.gov.
Chijioke UmunnakweViral Recombination Section, HIV Dynamics and Replication Progam, National Cancer Institute, Frederick, Maryland, USA.
David Q SunViral Recombination Section, HIV Dynamics and Replication Progam, National Cancer Institute, Frederick, Maryland, USA.
Olga A NikolaitchikViral Recombination Section, HIV Dynamics and Replication Progam, National Cancer Institute, Frederick, Maryland, USA.
Vinay K PathakViral Mutation Section, HIV Dynamics and Replication Program, National Cancer Institute, Frederick, Maryland, USA.
Ben BerkhoutLaboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Atze T DasLaboratory of Experimental Virology, Department of Medical Microbiology, Amsterdam University Medical Centers, Amsterdam, The Netherlands.
Wei-Shau HuViral Recombination Section, HIV Dynamics and Replication Progam, National Cancer Institute, Frederick, Maryland, USA chenjia@mail.nih.gov Wei-Shau.Hu@nih.gov.ORCID 0000-0001-7733-623X
National Cancer Institute · USAmsterdam University Medical Centers · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

HIV-1 full-length RNA (referred to as HIV-1 RNA here) serves as the viral genome in virions and as a template for Gag/Gag-Pol translation. We previously showed that HIV-1 RNA, which is exported via the CRM1 pathway, travels in the cytoplasm mainly through diffusion. A recent report suggested that the export pathway used by retroviral RNA could affect its cytoplasmic transport mechanism and localization. HIV-1 RNA export is directed by the viral protein Rev and the

Indexed as

Active Transport, Cell NucleusCell NucleusCytoplasmGene Products, revHIV-1HIV InfectionsHumansRNA TransportRNA, ViralGene Products, revRNA, ViralcytoplasmicdiffusiondistributionHIV-1nuclear exportRNAtransport mechanism

Identifiers

PMID33172997
PMCPMC7667035
OpenAlexW3103830673

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.