Evidence map›Paper›PMID 33172991›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Lipoteichoic acid polymer length is determined by competition between free starter units.

Anthony R Hesser, Kaitlin Schaefer, Wonsik Lee, Suzanne Walker

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Optimization of the Purification Process forJournal of microbiology and biotechnology · 2025
    Article
  5. SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  8. A novel polysaccharide in the envelope ofJournal of bacteriology · 2025
    Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Rapid Inhibitor Discovery by Exploiting Synthetic Lethality.Journal of the American Chemical Society · 2022
    Article
  19. Ftsh Sensitizes Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Anthony R HesserDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-5929-6825
Kaitlin SchaeferDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.
Wonsik LeeDepartment of Microbiology, Harvard Medical School, Boston, MA 02115.
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, MA 02115; suzanne_walker@hms.harvard.edu.ORCID 0000-0002-0545-914X

Funding

Technical Mother Machine CoreP01AI083214 · NIAID · SCHEPENS EYE RESEARCH INSTITUTE · PI Michael S Gilmore · 2009 to 2026
$39.4M
Release of Extracellular DNA during Biofilm Formation in Staphylococcus aureusR01AI139011 · NIAID · HARVARD UNIVERSITY · PI KAHNE, DANIEL, LOSICK, RICHARD MARC · 2018 to 2022
$3.2M
NIAID NIH HHS P01 AI083214NIAID NIH HHS R01 AI139011
6 · The paper itself

Abstract

Carbohydrate polymers exhibit incredible chemical and structural diversity, yet are produced by polymerases without a template to guide length and composition. As the length of carbohydrate polymers is critical for their biological functions, understanding the mechanisms that determine polymer length is an important area of investigation. Most Gram-positive bacteria produce anionic glycopolymers called lipoteichoic acids (LTA) that are synthesized by lipoteichoic acid synthase (LtaS) on a diglucosyl-diacylglycerol (Glc

Indexed as

Bacterial ProteinsCell MembraneGlycolipidsLipidsLipopolysaccharidesPolymersStaphylococcus aureusTeichoic AcidsBacterial Proteinsdiglucosyl diacylglycerolGlycolipidsLipidsLipopolysaccharideslipoteichoic acidPolymersTeichoic Acidslipoteichoic acidpolymeraseprocessivity

Identifiers

PMID33172991
PMCPMC7703640

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.