Evidence map›Paper›PMID 33172989›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Type I interferon remodels lysosome function and modifies intestinal epithelial defense.

Hailong Zhang, Abdelrahim Zoued, Xu Liu, Brandon Sit, Matthew K Waldor

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. NontyphoidalIDCases · 2025
    Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Exposing the Two Contrasting Faces of STAT2 in Inflammation.Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research · 2022
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hailong ZhangHoward Hughes Medical Insitute, Boston, MA 02115.ORCID 0000-0002-4903-010X
Abdelrahim ZouedHoward Hughes Medical Insitute, Boston, MA 02115.ORCID 0000-0002-6973-1755
Xu LiuHoward Hughes Medical Insitute, Boston, MA 02115.
Brandon SitDivision of Infectious Diseases, Brigham and Women's Hospital, Boston, MA 02115.ORCID 0000-0003-2378-3039
Matthew K WaldorHoward Hughes Medical Insitute, Boston, MA 02115; mwaldor@research.bwh.harvard.edu.ORCID 0000-0003-1843-7000
Brigham and Women's Hospital · US

Funding

Vibrio cholerae intestinal colonization and vaccine developmentR01AI042347 · NIAID · TUFTS UNIVERSITY BOSTON · PI WALDOR, MATTHEW K · 1998 to 2025
$7.3M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI042347
6 · The paper itself

Abstract

Organelle remodeling is critical for cellular homeostasis, but host factors that control organelle function during microbial infection remain largely uncharacterized. Here, a genome-scale CRISPR/Cas9 screen in intestinal epithelial cells with the prototypical intracellular bacterial pathogen

Indexed as

AnimalsBacterial ProteinsCRISPR-Cas SystemsDisease Models, AnimalEpithelial CellsGene Expression Regulation, BacterialHost-Pathogen InteractionsHT29 CellsHumansHydrogen-Ion ConcentrationImmunity, InnateInterferon Type IIntestinal MucosaLysosomesMiceMice, KnockoutBacterial ProteinsIfnar1 protein, mouseInterferon Type IPeptide HydrolasesReceptor, Interferon alpha-betaVirulence Factorsintestinal epitheliumlysosomemucosal defenseSalmonella pathogenesistype I interferon

Identifiers

PMID33172989
PMCPMC7703599
OpenAlexW3104179410

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.