Evidence map›Paper›PMID 33172988›Full record

ArticleJournal of cell science2020

RAS-mediated suppression of PAR3 and its effects on SCC initiation and tissue architecture occur independently of hyperplasia.

Ji Ling, Maria Sckaff, Manisha Tiwari, Yifang Chen, Jingting Li, Jackson Jones, George L Sen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. OncogenicScience advances · 2021
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Ji LingDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA.
Maria SckaffDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA.
Manisha TiwariDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA.
Yifang ChenDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA.
Jingting LiDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA.
Jackson JonesDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA.ORCID 0000-0002-6447-5166
George L SenDepartment of Dermatology, Department of Cellular and Molecular Medicine, UCSD Stem Cell Program, University of California, San Diego, La Jolla, CA 92093-0869, USA gsen@health.ucsd.edu.ORCID 0000-0003-1279-8550
University of California San Diego · US

Funding

Regulators of Epidermal Growth and DifferentiationR01AR066530 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEN, GEORGE L · 2015 to 2025
$4.0M
Regulators of Epidermal Homeostasis and TumorigenesisR01CA225463 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GEORGE L SEN · 2019 to 2026
$2.4M
Post-Transcriptional Regulators of Epidermal Homeostasis and NeoplasiaR01AR072590 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SEN, GEORGE L · 2018 to 2022
$1.9M
NCI NIH HHS R01 CA225463NIAMS NIH HHS R01 AR066530NIAMS NIH HHS R01 AR072590
6 · The paper itself

Abstract

Proper epithelial development and homeostasis depends on strict control of oriented cell division. Current evidence shows that this process is regulated by intrinsic polarity factors and external spatial cues. Owing to the lack of an appropriate model system that can recapitulate the architecture of the skin, deregulation of spindle orientation in human epithelial carcinoma has never been investigated. Here, using an inducible model of human squamous cell carcinoma (SCC), we demonstrate that RAS-dependent suppression of PAR3 (encoded by

Indexed as

Adaptor Proteins, Signal TransducingCarcinoma, Squamous CellCell Cycle Proteinsras ProteinsCarcinogenesisCell AdhesionCell DivisionCell PolarityHumansHyperplasiaSpindle ApparatusAdaptor Proteins, Signal TransducingCell Cycle ProteinsPARD3 protein, humanras ProteinsCell adhesionCell junctionEpidermisEpithelial organizationMitotic spindle orientationPolaritySkinTumorigenesis

Identifiers

PMID33172988
PMCPMC7746667
OpenAlexW3101026315

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.