ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021
Legumain Induces Oral Cancer Pain by Biased Agonism of Protease-Activated Receptor-2.
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Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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Who cites it
41 citing papers in PubMed, 54 citations in OpenAlex.
- Review
- MMP1 and PRSS23 induce PARCommunications biology · 2026Article
- Targeting CGRP signaling alleviates cancer-associated pain in oral squamous cell carcinoma.BMC oral health · 2026Article
- Nanoparticle-mediated antagonism of sustained endosomal signaling of the calcitonin receptor-like receptor provides enhanced and persistent relief of oral cancer pain.Biomaterials · 2026Article
- Lgmn targets two distinct GPCRs, PAR2 and µ-OR1, and induces cell death in acute lymphoblastic leukemia through an intracellular Ca²⁺ imbalance triggered by ER Ca²⁺ release.Cell death discovery · 2026Article
- Protease-activated receptors act as a liaison between metabolism and inflammation.Inflammopharmacology · 2026Review
- A Bacteroides fragilis protease activates host PARCell host & microbe · 2025Article
- Employing complementary fractionation-based N-terminomics approaches enhances the identification of legumain cleavage events in naïve and inflamed colon tissue.Protein science : a publication of the Protein Society · 2025Article
- L-asparaginase is a PAR2 N-terminal protease that unmasks the PAR2 tethered ligand.Cell death discovery · 2025Article
- PARBiomaterials · 2025Article
- N-terminomics profiling of naïve and inflamed murine colon reveals proteolytic signatures of legumain.Journal of cellular physiology · 2025Article
- TRPV4 activation in Schwann cells mediates mechanically induced pain of oral cancer.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- FTO-mediated demethylation of MTUS1/ATIP1 promotes tumor progression in head and neck squamous cell carcinoma.BMC cancer · 2024Article
- Melitoxin Inhibits Proliferation, Metastasis, and Invasion of Glioma U251 Cells by Down-regulating F2RL1.Applied biochemistry and biotechnology · 2024Article
- Investigation of prognostic values of immune infiltration and LGMN expression in the microenvironment of osteosarcoma.Discover oncology · 2024Article
- Par2-mediated responses in inflammation and regeneration: choosing between repair and damage.Inflammation and regeneration · 2024Review
- Stimulator of Interferon Genes Pathway Activation through the Controlled Release of STINGel Mediates Analgesia and Anti-Cancer Effects in Oral Squamous Cell Carcinoma.Biomedicines · 2024Article
- Update on protease-activated receptor 2 in inflammatory and autoimmune dermatological diseases.Frontiers in immunology · 2024Review
- Measurement of the Association of Pain with Clinical Characteristics in Oral Cancer Patients at Diagnosis and Prior to Cancer Treatment.Journal of pain research · 2024Article
- Mitochondrial outer membrane protein MTUS1/ATIP1 exerts antitumor effects through ROS-induced mitochondrial pyroptosis in head and neck squamous cell carcinoma.International journal of biological sciences · 2024Article
Corrections and comments
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Authors and funding
17 authors at 8 institutions in 3 countries.
Nguyen Huu TuOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Dane D JensenOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Bethany M AndersonBiochemistry and Molecular Biology, Bio21 Institute, University of Melbourne, Parkville, VIC 3010.ORCID 0000-0002-1663-1099
Elyssa ChenOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Nestor N Jimenez-VargasGastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 3N6, Canada.
Nicole N ScheffOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Kenji InoueOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Hung D TranOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
John C DolanOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010.
Tamaryn A MeekDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052.
Morley D HollenbergInflammation Research Network-Snyder Institute for Chronic Disease, Physiology and Pharmacology Department, and Medicine Department, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada.
Cheng Z LiuDepartment of Pathology, New York University Langone Health, New York, NY 10016.
Stephen J VannerGastrointestinal Diseases Research Unit, Division of Gastroenterology, Queen's University, Kingston, ON K7L 3N6, Canada.
Malvin N JanalDepartment of Epidemiology and Health Promotion, New York University College of Dentistry, New York, NY 10010.
Nigel W BunnettDepartment of Molecular Pathobiology, New York University College of Dentistry, New York, NY 10010.
Laura E Edgington-MitchellOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010 laura.edgingtonmitchell@unimelb.edu.au bls322@nyu.edu.
Brian L SchmidtOral and Maxillofacial Surgery, Bluestone Center for Clinical Research, New York University College of Dentistry, New York, NY 10010 laura.edgingtonmitchell@unimelb.edu.au bls322@nyu.edu.
Center for Clinical Research (United States) · USQueen's University · CAThe University of Melbourne · AUDiscovery Institute · USNew York University · USNYU Langone Health · USUniversity of Calgary · CAYork University · US
Funding
Targeting Endosomal Receptors for Treatment of Chronic PainR01DE029951 · NIDCR · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2020 to 2024
$4.7MProtease/PAR2/TRPV4 Axis and Oral Cancer PainR01DE026806 · NIDCR · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2022
$3.9MEndosomal Platforms for Signaling PainR01NS102722 · NINDS · NEW YORK UNIVERSITY · PI NIGEL W BUNNETT, Brian L Schmidt · 2017 to 2026
$3.4MTrafficking-Dependent Signaling of Pain by Protease-Activated ReceptorsR01DK118971 · NIDDK · NEW YORK UNIVERSITY · PI BUNNETT, NIGEL W, SCHMIDT, BRIAN L · 2018 to 2021
$3.2MNIDCR NIH HHS R01 DE026806NIDCR NIH HHS R01 DE029951NIDDK NIH HHS R01 DK118971NINDS NIH HHS R01 NS102722
Abstract
Oral squamous cell carcinoma (OSCC) is one of the most painful cancers, which interferes with orofacial function including talking and eating. We report that legumain (Lgmn) cleaves protease-activated receptor-2 (PAR
Indexed as
Cysteine EndopeptidasesAgedAged, 80 and overAnimalsArrestinAsparaginyl EndopeptidaseCancer PainCarcinoma, Squamous CellCyclic AMP-Dependent Protein KinasesEndocytosisEnzyme ActivationFemaleHumansMaleMiceMice, Inbred C57BLArrestinAsparaginyl EndopeptidaseCyclic AMP-Dependent Protein KinasesCysteine EndopeptidasesF2rl1 protein, mouseProtein Kinase Cprotein kinase DProtein Kinase InhibitorsReceptor, PAR-2asparaginyl endopeptidasecancer painlegumainoral cancerproteaseprotease-activated receptor-2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.