ArticleCancer research2021
Frizzled-7 Identifies Platinum-Tolerant Ovarian Cancer Cells Susceptible to Ferroptosis.
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In one paragraph
Article in Cancer research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 168 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
168citing papers in PubMed, 2 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
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Who cites it
168 citing papers in PubMed, 2 syntheses or guidelines pooled it, 240 citations in OpenAlex.
- The interaction between endoplasmic reticulum stress and ferroptosis in ovarian diseases.Journal of ovarian research · 2026Pooled it
- Drug resistance biomarkers in ovarian cancer: a bibliometric study from 2017 to 2022.Frontiers in oncology · 2024Pooled it
- FXN predicts poor prognosis in colon adenocarcinoma and correlates with immune cell infiltration.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Article
- Metabolic vulnerabilities in ovarian cancer decoding the nexus between nutrient adaptation and therapy resistance.Journal of advanced research · 2026Review
- Targeting the USP7-PRMT6 epigenetic axis overcomes chemoresistance in breast cancer by coordinating H3R2me2a deposition and RNF168 methylation for DNA repair and ferroptosis blockade.Cell death and differentiation · 2026Article
- Wnt/β-catenin signaling in hepatocellular carcinoma: a key player in resistance to targeted and immunotherapies.Carcinogenesis · 2026Review
- FZD7 Inhibitor SRI Attenuates High Glucose-Induced Retinal Pigment Epithelial Cell Injury Accompanied by Ferroptosis-Associated Changes via Suppression of the Wnt/β-Catenin Pathway.Endocrinology, diabetes & metabolism · 2026Article
- Ferroptosis and chemotherapy resistance in ovarian cancer: molecular mechanisms and therapeutic opportunities.Journal of ovarian research · 2026Review
- Oleic acid fuels cisplatin-resistant ovarian cancer through FABP4-driven lipid uptake.Molecular metabolism · 2026Article
- Ascites protects against ferroptosis and enables the peritoneal growth of ovarian cancer.Nature communications · 2026Article
- CC223 enhances cisplatin sensitivity of platinum-resistant ovarian cancer by inducing cell cycle arrest.Journal of ovarian research · 2026Article
- Platinum-resistant ovarian cancer: From mechanisms to treatment strategies.Genes & diseases · 2026Review
- TFAP2C protects against ferroptosis in ovarian cancer through the KEAP1-NRF2 axis by recruiting HDAC1/2.Oncogene · 2026Article
- Cell-intrinsic and tumor microenvironmental determinants of platinum resistance in epithelial ovarian cancer.Discover oncology · 2026Review
- CST4 promotes EMT and tumor progression in ovarian cancer via Wnt/β-catenin signaling.Discover oncology · 2026Article
- Targeting cancer stem cells predicts response and reverses chemoresistance in ascites-derived ovarian cancer organoids.BMC medicine · 2026Article
- MicroRNA mediated signaling and metabolic reprogramming in oral squamous cell carcinoma.Medical oncology (Northwood, London, England) · 2026Review
- Metabolic Dependency on De Novo Pyrimidine Synthesis Is a Targetable Vulnerability in Platinum-Resistant Ovarian Cancer.Cancer research · 2026Article
- Ferroptosis and metastasis: molecular checkpoints, microenvironmental dynamics, and therapeutic opportunities.Molecular cancer · 2026Review
- LF3 exerts anti-osteosarcoma effects through Wnt signaling inhibition-coupled ferroptosis induction viaFrontiers in oncology · 2026Article
108 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 1 country.
Yinu WangDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Guangyuan ZhaoDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID https://orcid.org/0000-0002-1095-8875
Salvatore CondelloDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, Indiana.
Hao HuangDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Horacio CardenasDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Edward J TannerDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.ORCID https://orcid.org/0000-0003-0829-1642
JianJun WeiDepartment of Pathology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.
Yanrong JiDivision of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, Illinois.ORCID https://orcid.org/0000-0002-0134-664X
Junjie LiDepartment of Physics, Boston University, Boston, Massachusetts.
Yuying TanDepartment of Physics, Boston University, Boston, Massachusetts.
Ramana V DavuluriDivision of Health and Biomedical Informatics, Department of Preventive Medicine, Northwestern University, Chicago, Illinois.
Marcus E PeterRobert H. Lurie Comprehensive Cancer Center, Chicago, Illinois.
Ji-Xin ChengDepartment of Physics, Boston University, Boston, Massachusetts.
Daniela MateiDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois. daniela.matei@northwestern.edu.ORCID https://orcid.org/0000-0003-2169-5035
Northwestern University · USBoston University · USIndiana University – Purdue University Indianapolis · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Daniela E Matei · 1993 to 2026
$153.9MDISE - a natural cancer surveillance mechanism - a new road to cancer therapyR35CA197450 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PETER, MARCUS E. · 2015 to 2021
$6.2MVibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7MTargeting Lipid Unsaturation in Ovarian Cancer Stem CellsR01CA224275 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Ji-Xin Cheng, Daniela E Matei · 2018 to 2026
$3.6MInformatics Platform for Mammalian Gene Regulation at Isoform-levelR01LM011297 · NLM · WISTAR INSTITUTE · PI DAVULURI, RAMANA V · 2013 to 2020
$2.4MDeveloping Novel Deep-Learning Based Methods for Deciphering Non-Coding Gene Regulatory CodeR01LM013722 · NLM · STATE UNIVERSITY NEW YORK STONY BROOK · PI RAMANA V DAVULURI · 2021 to 2026
$2.0MBLRD VA I01 BX000792NCI NIH HHS P30 CA060553NCI NIH HHS R01 CA224275NCI NIH HHS R35 CA197450NIGMS NIH HHS R35 GM136223NLM NIH HHS R01 LM011297NLM NIH HHS R01 LM013722
Abstract
Defining traits of platinum-tolerant cancer cells could expose new treatment vulnerabilities. Here, new markers associated with platinum-tolerant cells and tumors were identified using
Indexed as
Drug Resistance, NeoplasmFerroptosisAnimalsAntineoplastic AgentsApoptosisBiomarkers, TumorCell ProliferationCisplatinFemaleFrizzled ReceptorsGene Expression Regulation, NeoplasticHumansMiceMice, NudeMiddle AgedNeoplastic Stem CellsAntineoplastic AgentsBiomarkers, TumorCisplatinFrizzled ReceptorsFZD7 protein, human
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.