Evidence map›Paper›PMID 33172925›Full record

ArticleGut2021

Do proton pump inhibitors influence SARS-CoV-2 related outcomes? A meta-analysis.

Guo-Fu Li, Xiao-Xiao An, Yichao Yu, Li-Rong Jiao, Daniele Canarutto, Guo Yu, Guangji Wang, Dan-Na Wu, Yin Xiao

Abstract readLetterComment
In one paragraph

Article in Gut, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Proton Pump Inhibitor Use Is Not Strongly Associated With SARS-CoV-2 Related Outcomes: A Nationwide Study and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2021
    Pooled it
  2. Pooled it
  3. Has the COVID-19 pandemic affected the incidence ofTurkish journal of surgery · 2025
    Article
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  12. HJournal of anesthesia · 2022
    Article
  13. Article
  14. Article
  15. Article
  16. Inflammation at the crossroads ofFuture microbiology · 2022
    Article
  17. Proton pump inhibitors in the COVID-19 pandemic.Gastroenterologia y hepatologia · 2021
    Article
  18. Anaesthesia-related drugs and SARS-CoV-2 infection.British journal of anaesthesia · 2021
    Article
  19. COVID-19-associated diarrhea.World journal of gastroenterology · 2021
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Guo-Fu LiClinical Medical College, Yangzhou University, Yangzhou, China.ORCID 0000-0002-4628-9941
Xiao-Xiao AnInstitution of Drug Clinical Trial, Subei People's Hospital, Yangzhou, China.
Yichao YuDepartment of Pharmaceutics, University of Florida, Gainesville, Florida, USA.
Li-Rong JiaoInstitution of Drug Clinical Trial, Subei People's Hospital, Yangzhou, China.
Daniele CanaruttoFaculty of Medicine and Surgery, Vita Salute San Raffaele University, Milan, Italy.
Guo YuClinical Medical College, Yangzhou University, Yangzhou, China guoyu@yzu.edu.cn.ORCID 0000-0001-6685-2167
Guangji WangKey Laboratory of Drug Metabolism and Pharmacokinetics, China Pharmaceutical University, Nanjing, China.
Dan-Na WuDepartment of Pharmacy, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, China.
Yin XiaoDepartment of Pharmacy, Haikou Affiliated Hospital of Central South University Xiangya School of Medicine, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19Gastroesophageal RefluxHumansProton Pump InhibitorsSARS-CoV-2Proton Pump Inhibitorsacid secretiongastric acidgastroesophageal reflux disease

Identifiers

PMID33172925
PMCPMC8355875

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.