Evidence map›Paper›PMID 33172920›Full record

ArticlePediatrics2020

Behavior Problems During Early Childhood in Children With Prenatal Methamphetamine Exposure.

Elaine K Chu, Lynne M Smith, Chris Derauf, Elana Newman, Charles R Neal, Amelia M Arria, Marilyn A Huestis, Sheri A DellaGrotta, Mary B Roberts, Lynne M Dansereau and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Methamphetamine: burden, mechanism and impact on pregnancy, the fetus, and newborn.Journal of perinatology : official journal of the California Perinatal Association · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 9 institutions in 1 country.

Elaine K ChuDepartment of Pediatrics, Lundquist Institute, Harbor-University of California, Los Angeles Medical Center and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Lynne M SmithDepartment of Pediatrics, Lundquist Institute, Harbor-University of California, Los Angeles Medical Center and David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California; smith@lundquist.org.
Chris DeraufDivision of Community and Pediatric Adolescent Medicine, Mayo Clinic, Rochester, Minnesota.
Elana NewmanDepartment of Psychology, The University of Tulsa, Tulsa, Oklahoma.
Charles R NealDepartment of Pediatrics, University of Hawai'i at Mānoa, Honolulu, Hawaii.
Amelia M ArriaDepartment of Family Science and Center on Young Adult Health and Development, School of Public Health, University of Maryland, College Park, Maryland.
Marilyn A HuestisIntramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland; and.
Sheri A DellaGrottaBrown Center for the Study of Children at Risk, Warren Alpert Medical School, Brown University and Women and Infants Hospital of Rhode Island, Providence, Rhode Island.
Mary B RobertsBrown Center for the Study of Children at Risk, Warren Alpert Medical School, Brown University and Women and Infants Hospital of Rhode Island, Providence, Rhode Island.
Lynne M DansereauBrown Center for the Study of Children at Risk, Warren Alpert Medical School, Brown University and Women and Infants Hospital of Rhode Island, Providence, Rhode Island.
Barry M LesterBrown Center for the Study of Children at Risk, Warren Alpert Medical School, Brown University and Women and Infants Hospital of Rhode Island, Providence, Rhode Island.
Women & Infants Hospital of Rhode Island · USBrown University · USLos Angeles Medical Center · USMayo Clinic · USNational Institutes of Health · USUniversity of California, Los Angeles · USUniversity of Hawaiʻi at Mānoa · USUniversity of Maryland, College Park · USUniversity of Tulsa · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
WILLINGNESS OF PRIMARY CARE PHYSICIANS TO ADOPT HANDHELD COMPUTINGP20RR011091 · NCRR · UNIVERSITY OF HAWAII AT MANOA · PI ERDEM, GULIZ · 1995 to 2009
$16.5M
Prental Methamphetamine Exposure and Child DevelopmentR01DA014948 · NIDA · WOMEN AND INFANTS HOSPITAL-RHODE ISLAND · PI LESTER, BARRY M. · 2001 to 2013
$14.5M
NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1 TR001881NCRR NIH HHS P20 RR011091NIDA NIH HHS R01 DA014948
6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe effects of in utero methamphetamine exposure on behavioral problems in school-aged children are unclear. Our objective for this study was to evaluate behavior problems in children at aged 3, 5, and 7.5 years who were prenatally exposed to methamphetamine.

methodsSubjects were enrolled in the Infant Development, Environment, and Lifestyle study, a longitudinal prospective study of prenatal methamphetamine exposure and child outcomes. Exposed and comparison groups were matched on birth weight, race, education, and health insurance.  At ages 3, 5, and 7.5 years, 339 children (171 exposed) were assessed for behavior problems by using the Child Behavior Checklist. Generalized estimating equations were used to determine the effects of prenatal methamphetamine exposure, age, and the interaction of exposure and age on behavior problems. Caregiver psychological symptoms were assessed by using the Brief Symptom Inventory.

resultsAnalyses adjusted for covariates revealed that relative to age 3, children at 5 years had less externalizing and aggressive behavior and more internalizing behavior, somatic complaints, and withdrawn behavior.  By age 7.5, aggressive behavior continued to decrease, attention problems increased and withdrawn behavior decreased. There were no main effects for methamphetamine exposure and no interactions of exposure and age.  Caregiver psychological symptoms predicted all behavior problems and the quality of the home predicted externalizing problems and externalizing syndrome scores.

conclusionsBehavioral effects longitudinally from ages 3 to 7.5 years were not associated with prenatal methamphetamine exposure, whereas caregiver psychological symptoms and the quality of the home were predictors of behavior problems.

Indexed as

Life StyleBirth WeightCentral Nervous System StimulantsChildChild Behavior DisordersChild DevelopmentChild, PreschoolFemaleFollow-Up StudiesHumansInfantMaleMethamphetaminePregnancyPrenatal Exposure Delayed EffectsProspective StudiesCentral Nervous System StimulantsMethamphetamine

Identifiers

PMID33172920
PMCPMC7706113
OpenAlexW3098546087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.