Evidence map›Paper›PMID 33172654›Full record

ArticleJournal of psychiatric research2021

Identifying subtypes of trichotillomania (hair pulling disorder) and excoriation (skin picking) disorder using mixture modeling in a multicenter sample.

Jon E Grant, Tara S Peris, Emily J Ricketts, Christine Lochner, Dan J Stein, Jan Stochl, Samuel R Chamberlain, Jeremiah M Scharf, Darin D Dougherty, Douglas W Woods and 2 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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  11. Temperament in trichotillomania and skin picking disorder.Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists · 2023
    Article
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  16. Trichotillomania and Skin-Picking Disorder: An Update.Focus (American Psychiatric Publishing) · 2021
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  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jon E GrantDepartment of Psychiatry & Behavioral Neuroscience University of Chicago, Chicago, IL, USA. Electronic address: jongrant@uchicago.edu.
Tara S PerisDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Emily J RickettsDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Christine LochnerDepartment of Psychiatry, University of Stellenbosch, South Africa.
Dan J SteinSA MRC Unit on Risk & Resilience in Mental Disorders, Dept of Psychiatry & Neuroscience Institute, University of Cape Town, South Africa.
Jan StochlDepartment of Psychiatry, University of Cambridge, Cambridge, UK; Department of Kinanthropology, Charles University, Prague, Czech Republic.
Samuel R ChamberlainDepartment of Psychiatry, University of Cambridge, Cambridge, UK.
Jeremiah M ScharfDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Darin D DoughertyDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.
Douglas W WoodsDepartment of Psychology, Marquette University, Milwaukee, WI, USA.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA.
Nancy J KeuthenDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Boston, USA.

Funding

Re-Engineering Translational Research at the University of ChicagoUL1TR000430 · NCATS · UNIVERSITY OF CHICAGO · PI SOLWAY, JULIAN · 2012 to 2016
$20.2M
NCATS NIH HHS UL1 TR000430Wellcome Trust 110049Wellcome Trust 110049/Z/15/Z
6 · The paper itself

Abstract

Body-focused repetitive behavior disorders (BFRBs) include Trichotillomania (TTM; Hair pulling disorder) and Excoriation (Skin Picking) Disorder (SPD). These conditions are prevalent, highly heterogeneous, under-researched, and under-treated. In order for progress to be made in optimally classifying and treating these conditions, it is necessary to identify meaningful subtypes. 279 adults (100 with TTM, 81 with SPD, 40 with both TTM and SPD, and 58 controls) were recruited for an international, multi-center between-group comparison using mixture modeling, with stringent correction for multiple comparisons. The main outcome measure was to examine distinct subtypes (aka latent classes) across all study participants using item-level data from gold-standard instruments assessing detailed clinical measures. Mixture models identified 3 subtypes of TTM (entropy 0.98) and 2 subtypes of SPD (entropy 0.99) independent of the control group. Significant differences between these classes were identified on measures of disability, automatic and focused symptoms, perfectionism, trait impulsiveness, and inattention and hyperactivity. These data indicate the existence of three separate subtypes of TTM, and two separate subtypes of SPD, which are distinct from controls. The identified clinical differences between these latent classes may be useful to tailor future treatments by focusing on particular traits. Future work should examine whether these latent subtypes relate to treatment outcomes, or particular psychobiological findings using neuroimaging techniques.

Indexed as

TrichotillomaniaAdultHumansClassificationMixture modelingSkin picking disorderSubtypesTreatmentTrichotillomania

Identifiers

PMID33172654
PMCPMC7610704

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.