ArticleBMC nephrology2020
Elevated alanine aminotransferase and low aspartate aminotransferase/alanine aminotransferase ratio are associated with chronic kidney disease among middle-aged women: a cross-sectional study.
Article in BMC nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- Relationship of HOMA-IR with chronic kidney disease in diabetic and non-diabetic Chinese populations: findings from the REACTION study.Frontiers in endocrinology · 2026Article
- Data-driven phenotypic profiling of prediabetes reveals heterogeneous cardiometabolic risks in Chinese adults.Cardiovascular diabetology · 2025Article
- Association of triglyceride-glucose index with diabetic kidney disease in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- OxyVitaInternational journal of molecular sciences · 2025Article
- Elevated Pulse Pressure and Risk of Chronic Kidney Disease by Hypertension Status: A Longitudinal Study in Japanese Adults.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2025Article
- Association Between Uric Acid to HDL-C Ratio and Liver Transaminase Abnormalities: Insights from a Large-Scale General Population Study.Medicina (Kaunas, Lithuania) · 2025Article
- Aspartate/alanine aminotransferase ratio and development of chronic kidney disease in non-diabetic men and women: a population-based longitudinal study in Kagawa, Japan.Clinical and experimental nephrology · 2025Article
- Weight-adjusted-waist index is associated with urinary albumin-creatinine ratio in normal body mass index adults: a cross-sectional study from NHANES 2001-2018.Scientific reports · 2025Article
- Association between the ratio of aspartate aminotransferase to alanine aminotransferase and risk of diabetes and the mediating effect of BMI: a comparative analysis in Chinese and Japanese populations.Frontiers in endocrinology · 2025Article
- The ratio of high aspartate aminotransferase to alanine aminotransferase: an independent risk factor associated with poor prognosis in IgA nephropathy.Clinical and experimental nephrology · 2024Article
- Clinical Evidence of the Relationship Between Alanine Aminotransferase and Diabetic Kidney Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Curvilinear association between Framingham Steatosis Index and chronic kidney disease: a nationwide cross-sectional study.Frontiers in medicine · 2024Article
- Association between elevated serum transaminase and moderately increased albuminuria: a cross-sectional study in western Tokushima, Japan.BMC nephrology · 2023Article
- The relationship between serum γ-glutamyltransferase (GGT) and diabetic nephropathy in patients with type 2 diabetes mellitus: a cross-sectional study.Clinical and experimental medicine · 2023Article
- Association of AST/ALT (De Ritis) ratio with sarcopenia in a Chinese population of community-dwelling elderly.Heliyon · 2023Article
- Associations of non-invasive indices of liver steatosis and fibrosis with progressive kidney impairment in adults with type 2 diabetes.Acta diabetologica · 2023Article
- Beneficial and adverse effects of vitamin E on the kidney.Frontiers in physiology · 2023Review
- The association between liver fibrosis scores and chronic kidney disease.Frontiers in medicine · 2023Article
- Residual Level, Histology, and Blood Biochemistry of Tebuconazole: A Repeated Dose 28-Day Oral Toxicity Study in Pigs.Food science of animal resources · 2022Article
- Low aspartate aminotransferase/alanine aminotransferase (DeRitis) ratio assists in predicting diabetes in Chinese population.Frontiers in public health · 2022Article
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7 authors at 1 institution in 1 country.
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Abstract
backgroundAlanine aminotransferase (ALT) and aspartate aminotransferase (AST) to ALT ratio (AST/ALT ratio) have been shown to be related to non-alcoholic fatty liver disease or insulin resistance, which was associated with chronic kidney disease (CKD). However, it is unclear whether ALT and AST/ALT ratio are associated with CKD. In this study, we examined the relationship of ALT and AST/ALT ratio to CKD among middle-aged females in Japan.
methodsThe present study included 29,133 women aged 40 to 64 years who had an annual health checkup in Japan during April 2013 to March 2014. Venous blood samples were collected to measure ALT, AST, gamma-glutamyltransferase (GGT), and creatinine levels. In accordance with previous studies, ALT > 40 U/L and GGT > 50 U/L were determined as elevated, AST/ALT ratio < 1 was regarded as low, and CKD was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m
results"Elevated ALT and elevated GGT" and "elevated ALT and non-elevated GGT" significantly increased the OR for CKD when compared with "non-elevated ALT and non-elevated GGT" (OR: 2.56, 95% CI: 2.10-3.12 and OR: 2.24, 95% CI: 1.81-2.77). Compared with "AST/ALT ratio ≥ 1 and non-elevated GGT", "AST/ALT ratio < 1 and elevated GGT" and "AST/ALT ratio < 1 and non-elevated GGT" significantly increased the OR for CKD (OR: 2.73, 95% CI: 2.36-3.15 and OR: 1.68, 95% CI: 1.52-1.87). These findings still remained after adjustment for confounders.
conclusionsElevated ALT was associated with CKD regardless of GGT elevation. Moreover, low AST/ALT ratio was also associated with CKD independent of GGT elevation.
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