Evidence map›Paper›PMID 33172355›Full record

ArticleVirulence2020

Novel biomarkers for the prediction of COVID-19 progression a retrospective, multi-center cohort study.

Yalan Yu, Tao Liu, Liang Shao, Xinyi Li, Colin K He, Muhammad Jamal, Yi Luo, Yingying Wang, Yanan Liu, Yufeng Shang and 3 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Virulence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Serum amyloid A concentrations, COVID-19 severity and mortality: An updated systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yalan YuDepartment of Hematology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0003-0293-7510
Tao LiuDepartment of Urology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0002-4202-8218
Liang ShaoDepartment of Hematology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0001-9066-8503
Xinyi LiDepartment of Anesthesiology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0002-8415-0385
Colin K HeOrient Health Care, Stego Tech LLC , King of Prussia, PA, USA.ORCID 0000-0001-8769-5308
Muhammad JamalDepartment of Immunology, School of Basic Medical Science, Wuhan University , Wuhan, China.ORCID 0000-0002-5625-4021
Yi LuoDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0001-6304-5626
Yingying WangDepartment of Hematology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0002-3923-8206
Yanan LiuDepartment of Hematology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0003-4244-7161
Yufeng ShangDepartment of Hematology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0003-0853-2709
Yunbao PanDepartment of Laboratory Medicine, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0002-6311-2945
Xinghuan WangEvidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0003-3497-0024
Fuling ZhouDepartment of Hematology, Zhongnan Hospital of Wuhan University , Wuhan, China.ORCID 0000-0003-0982-0382
Wuhan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A pandemic designated as Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading worldwide. Up to date, there is no efficient biomarker for the timely prediction of the disease progression in patients. To analyze the inflammatory profiles of COVID-19 patients and demonstrate their implications for the illness progression of COVID-19. Retrospective analysis of 3,265 confirmed COVID-19 cases hospitalized between 10 January 2020, and 26 March 2020 in three medical centers in Wuhan, China. Patients were diagnosed as COVID-19 and hospitalized in Leishenshan Hospital, Zhongnan Hospital of Wuhan University and The Seventh Hospital of Wuhan, China. Univariable and multivariable logistic regression models were used to determine the possible risk factors for disease progression. Moreover, cutoff values, the sensitivity and specificity of inflammatory parameters for disease progression were determined by MedCalc Version 19.2.0. Age (95%CI, 1.017 to 1.048;

Indexed as

AgedArea Under CurveBetacoronavirusBiomarkersBlood SedimentationChinaCohort StudiesCoronavirus InfectionsCOVID-19C-Reactive ProteinDisease ProgressionFemaleHumansLarynxLeukocyte CountLogistic ModelsBiomarkersC-Reactive ProteinRNA, ViralSerum Amyloid A ProteinbiomarkerCOVID-19disease progressionpredictorrisk factorserum amyloid A protein

Identifiers

PMID33172355
PMCPMC7671095
OpenAlexW3100639752

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.