ReviewInternational journal of molecular sciences2020
Germinal Matrix-Intraventricular Hemorrhage of the Preterm Newborn and Preclinical Models: Inflammatory Considerations.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 57 citations in OpenAlex.
- Delayed microglial depletion protects against white matter injury following neonatal cerebral hemorrhage in mice.Neural regeneration research · 2026Article
- Hemostatic B-knob-triggered microgels (BK-TriGs) to address bleeding in neonates.Science advances · 2026Article
- Exposure to enriched environment and parental care ameliorates brain pathology and behavioral impairment after germinal-matrix intraventricular hemorrhage.Molecular psychiatry · 2026Article
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Predictive model for severe intraventricular hemorrhage risk in preterm infants: a systematic review and meta-analysis.Frontiers in pediatrics · 2026Review
- Subventricular Zone-on-a-Chip: A Model to Study Neurogenesis Disruption in Neonatal Intraventricular Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Predicting severe intraventricular hemorrhage in very preterm and/or very low birth weight infants: a nomogram approach.Frontiers in pediatrics · 2026Article
- Feasibility Study on Inflammasome Proteins as Biomarkers in the Cerebrospinal Fluid of Pediatric Patients with Hydrocephalus Due to Intraventricular Hemorrhage.Biomolecules · 2025Article
- Vitamin E for intraventricular hemorrhage prevention in preterm neonates: A systematic review and meta-analysis.Neuroprotection (Chichester, England) · 2025Article
- Glycogen Synthase Kinase-3β Inhibitor VP3.15 Ameliorates Neurogenesis, Neuronal Loss and Cognitive Impairment in a Model of Germinal Matrix-intraventricular Hemorrhage of the Preterm Newborn.Translational stroke research · 2025Article
- Preliminary feasibility study on DTI to assess the early brain injury in germinal matrix-intraventricular hemorrhage rats.Scientific reports · 2025Article
- Development and validation of a clinical features-based nomogram for predicting neonatal cerebral microbleeds.Quantitative imaging in medicine and surgery · 2025Article
- Choroid Plexus Pathophysiology.Annual review of pathology · 2025Review
- Influencing factors and construction of a predictive model for neurodevelopmental outcomes in preterm low birth weight infants.American journal of translational research · 2025Article
- Noninvasive optical monitoring of cerebral hemodynamics in a preclinical model of neonatal intraventricular hemorrhage.Frontiers in pediatrics · 2025Article
- Contemporary mortality of neonatal germinal matrix hemorrhage and incidence of hydrocephalus requiring cerebrospinal fluid diversion in a substantially rural patient population.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Associations between diffusion kurtosis imaging metrics and neurodevelopmental outcomes in neonates with low-grade germinal matrix and intraventricular hemorrhage.Scientific reports · 2024Article
- Could we detect intraventricular hemorrhage before it happens?Pediatric research · 2024Article
- Risk factors associated with intraventricular hemorrhage in very-low-birth-weight premature infants.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Article
- Treatment of preterm brain injury via gut-microbiota-metabolite-brain axis.CNS neuroscience & therapeutics · 2024Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The germinal matrix-intraventricular hemorrhage (GM-IVH) is one of the most important complications of the preterm newborn. Since these children are born at a critical time in brain development, they can develop short and long term neurological, sensory, cognitive and motor disabilities depending on the severity of the GM-IVH. In addition, hemorrhage triggers a microglia-mediated inflammatory response that damages the tissue adjacent to the injury. Nevertheless, a neuroprotective and neuroreparative role of the microglia has also been described, suggesting that neonatal microglia may have unique functions. While the implication of the inflammatory process in GM-IVH is well established, the difficulty to access a very delicate population has lead to the development of animal models that resemble the pathological features of GM-IVH. Genetically modified models and lesions induced by local administration of glycerol, collagenase or blood have been used to study associated inflammatory mechanisms as well as therapeutic targets. In the present study we review the GM-IVH complications, with special interest in inflammatory response and the role of microglia, both in patients and animal models, and we analyze specific proteins and cytokines that are currently under study as feasible predictors of GM-IVH evolution and prognosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.