Evidence map›Paper›PMID 33172148›Full record

ArticleGenes2020

Autophagy Genes for Wet Age-Related Macular Degeneration in a Finnish Case-Control Study.

Jussi J Paterno, Ali Koskela, Juha M T Hyttinen, Elina Vattulainen, Ewelina Synowiec, Raimo Tuuminen, Cezary Watala, Janusz Blasiak, Kai Kaarniranta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Consequences of Aging on Bone.Aging and disease · 2023
    Pooled it
  2. Functional polymorphisms in pigmentation-related genesBiochemistry and biophysics reports · 2026
    Article
  3. Exploiting autophagy and related pathways: pioneering new horizons in cataract therapy.Apoptosis : an international journal on programmed cell death · 2025
    Review
  4. Review
  5. Review
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Jussi J PaternoDepartment of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland.
Ali KoskelaDepartment of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland.
Juha M T HyttinenDepartment of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland.
Elina VattulainenDepartment of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland.
Ewelina SynowiecFaculty of Biology and Environmental Protection, Department of Molecular Genetics, University of Lodz, 90-136 Lodz, Poland.
Raimo TuuminenHelsinki Retina Research Group, University of Helsinki, 00014 Helsinki, Finland and Department of Ophthalmology, Kymenlaakso Central Hospital, 48100 Kotka, Finland.ORCID 0000-0003-1550-8125
Cezary WatalaDepartment of Haemostatic Disorders, Chair of Biomedical Sciences, Medical University, 92-215 Lodz, Poland.ORCID 0000-0002-5627-7872
Janusz BlasiakFaculty of Biology and Environmental Protection, Department of Molecular Genetics, University of Lodz, 90-136 Lodz, Poland.ORCID 0000-0001-9539-9584
Kai KaarnirantaDepartment of Ophthalmology, University of Eastern Finland, 70211 Kuopio, Finland.
University of Eastern Finland · FIUniversity of Łódź · PLMedical University of Lodz · PLUniversity of Helsinki · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration is an eye disease that is the main cause of legal blindness in the elderly in developed countries. Despite this, its pathogenesis is not completely known, and many genetic, epigenetic, environmental and lifestyle factors may be involved. Vision loss in age-related macular degeneration (AMD) is usually consequence of the occurrence of its wet (neovascular) form that is targeted in the clinic by anti-VEGF (vascular endothelial growth factor) treatment. The wet form of AMD is associated with the accumulation of cellular waste in the retinal pigment epithelium, which is removed by autophagy and the proteosomal degradation system. In the present work, we searched for the association between genotypes and alleles of single nucleotide polymorphisms (SNPs) of autophagy-related genes and wet AMD occurrence in a cohort of Finnish patients undergoing anti-VEGF therapy and controls. Additionally, the correlation between treatment efficacy and genotypes was investigated. Overall, 225 wet AMD patients and 161 controls were enrolled in this study. Ten SNPs (rs2295080, rs11121704, rs1057079, rs1064261, rs573775, rs11246867, rs3088051, rs10902469, rs73105013, rs10277) in the

Indexed as

AgedAged, 80 and overAllelesAutophagyAutophagy-Related Protein-1 HomologAutophagy-Related Protein 5Case-Control StudiesCohort StudiesFemaleFinlandGenotypeHumansIntracellular Signaling Peptides and ProteinsMacular DegenerationMaleMicrotubule-Associated ProteinsATG5 protein, humanAutophagy-Related Protein-1 HomologAutophagy-Related Protein 5Intracellular Signaling Peptides and ProteinsMAP1LC3A protein, humanMicrotubule-Associated ProteinsMTOR protein, humanSequestosome-1 ProteinSQSTM1 protein, humanTOR Serine-Threonine KinasesULK1 protein, humanVascular Endothelial Growth Factor Aagingautophagydegenerationmaculaneovascularization

Identifiers

PMID33172148
PMCPMC7694766
OpenAlexW3097952698

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.