Evidence map›Paper›PMID 33172141›Full record

ArticleMolecules (Basel, Switzerland)2020

Tetrapodal Anion Transporters.

Alexander M Gilchrist, Lijun Chen, Xin Wu, William Lewis, Ethan N W Howe, Lauren K Macreadie, Philip A Gale

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Synthetic NaChem · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Alexander M GilchristSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.ORCID 0000-0002-3583-6372
Lijun ChenSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.
Xin WuSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.
William LewisSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.ORCID 0000-0001-7103-6981
Ethan N W HoweSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.
Lauren K MacreadieSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.
Philip A GaleSchool of Chemistry (F11), The University of Sydney, Sydney 2006, Australia.ORCID 0000-0001-9751-4910
The University of Sydney · AU

Funding

Australian Research Council DP180100612
6 · The paper itself

Abstract

Synthetic anion transporters that facilitate chloride transport are promising candidates for channelopathy treatments. However, most anion transporters exhibit an undesired side effect of facilitating proton transport via interacting with fatty acids present in the membrane. To address the limitation, we here report the use of a new tetrapodal scaffold to maximize the selective interaction with spherical chloride over binding the carboxylate headgroup of fatty acids. One of the new transporters demonstrated a high selectivity for chloride uniport over fatty acid-induced proton transport while being >10 times more active in chloride uniport than strapped calixpyrroles that were previously the only class of compounds known to possess similar selectivity properties.

Indexed as

AnionsAnion Transport ProteinsChloridesChromatography, Thin LayerCrystallography, X-RayFatty AcidsIon TransportLipid BilayersMagnetic Resonance SpectroscopyNitratesPyrenesSulfonic Acids8-hydroxy-1,3,6-pyrenetrisulfonic acidAnionsAnion Transport ProteinsChloridesFatty AcidsLipid BilayersNitratesPyrenesSulfonic Acidsanion-selective transportanion transportlipid bilayersupramolecular chemistry

Identifiers

PMID33172141
PMCPMC7664440
OpenAlexW3095456631

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.