ArticleInternational journal of environmental research and public health2020
Associations between Levels of Urinary Oxidative Stress of 8-OHdG and Risk of Atopic Diseases in Children.
Article in International journal of environmental research and public health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 36 citations in OpenAlex.
- A Multilevel Redox-Based Prognostic Model for Asthma Severity: From Genotype to Serum Biomarkers.Biomedicines · 2026Review
- Oxidative and Nitrosative Stress in Atopic Dermatitis and Depression: Similarities in Biomarkers and Pathophysiological Mechanisms.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
- Metabolomics-Based Analysis Linking Oxidative Stress-Related Branched-Chain Amino Acid (BCAA) Pathway with Atopic Indices to Childhood Allergies.Antioxidants (Basel, Switzerland) · 2026Article
- Role of Oxidative Stress and Antioxidants in the Course of Atopic Dermatitis.International journal of molecular sciences · 2025Review
- Oxidative stress products and managements in atopic dermatitis.Frontiers in medicine · 2025Review
- An Overview on Atopic Dermatitis, Oxidative Stress, and Psychological Stress: Possible Role of Nutraceuticals as an Additional Therapeutic Strategy.International journal of molecular sciences · 2024Review
- Metal and oxidative potential exposure through particle inhalation and oxidative stress biomarkers: a 2-week pilot prospective study among Parisian subway workers.International archives of occupational and environmental health · 2024Article
- Cell-free fat extract regulates oxidative stress and alleviates Th2-mediated inflammation in atopic dermatitis.Frontiers in bioengineering and biotechnology · 2024Article
- Comparative Analysis of Redox Homeostasis Biomarkers in Patients with Psoriasis and Atopic Dermatitis.Antioxidants (Basel, Switzerland) · 2023Article
- Plasma 8-OHdG act as a biomarker for steroid-induced osteonecrosis of the femoral head.BMC musculoskeletal disorders · 2023Article
- Thiol-Disulfide Homeostasis in Skin Diseases.Journal of clinical medicine · 2022Review
- Current Insights into Atopic March.Children (Basel, Switzerland) · 2021Review
- Melatonin prevents allergic airway inflammation in epicutaneously sensitized mice.Bioscience reports · 2021Article
- Effect of Preconception Selenium Intake on the Risk for Gestational Diabetes: The Japan Environment and Children's Study.Antioxidants (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The oxidative stress biomarker of urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) was reported to be changed in patients with allergic diseases. Measurement of urinary oxidative products is noninvasive. However, correlations between the severity levels of atopic diseases and oxidative stress remain unclear. This study aimed to investigate the association among urinary 8-OHdG, atopic dermatitis (AD), and the phenotypes of atopic diseases in children. In a nested case-control study, participants of kindergarten children were enrolled from the Childhood Environment and Allergic Diseases Study (CEAS). Urinary analyses and urinary 8-OHdG were performed on samples from 200 children with AD as cases and 200 age- and sex-matched controls. Our study presents the following main findings: (1) The urinary 8-OHdG levels were significantly higher in cases than controls. Higher urinary 8-OHdG levels were associated with the risk of AD in a dose-response-manner; (2) Children's AD history was associated with higher risks of asthma, allergic rhinitis, and night pruritus; (3) For children with AD, urinary 8-OHdG levels of >75th percentile were associated with higher risk of asthma, compared with the reference group of 0-25th percentiles. In summary, this study provides better understanding of the underlying mechanisms of AD and urinary 8-OHdG by analyzing a large-scale sample survey in Taiwan.
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