Evidence map›Paper›PMID 33171884›Full record

ArticleMaterials (Basel, Switzerland)2020

Adsorption of Chiral [5]-Aza[5]helicenes on DNA Can Modify Its Hydrophilicity and Affect Its Chiral Architecture: A Molecular Dynamics Study.

Giuseppina Raffaini, Andrea Mele, Tullio Caronna

Open access · goldAbstract read
In one paragraph

Article in Materials (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Giuseppina RaffainiDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza L. Da Vinci 32, 20131 Milano, Italy.ORCID 0000-0003-3462-6514
Andrea MeleDepartment of Chemistry, Materials and Chemical Engineering "Giulio Natta", Politecnico di Milano, Piazza L. Da Vinci 32, 20131 Milano, Italy.ORCID 0000-0002-0351-0538
Tullio CaronnaDipartimento di Ingegneria e Scienze Applicate, Università degli Studi di Bergamo, 24044 Bergamo, Italy.
National Interuniversity Consortium of Materials Science and Technology · ITPolitecnico di Milano · ITUniversity of Bergamo · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicenes are interesting chiral molecules without asymmetric carbon atoms but with intrinsic chirality. Functionalized 5-Aza[5]helicenes can form non-covalent complexes with anticancer drugs and therefore be potential carriers. The paper highlights the different structural selectivity for DNA binding for two enantiopure compounds and the influence of concentration on their adsorption and self-aggregation process. In this theoretical study based on atomistic molecular dynamics simulations the interaction between (

Indexed as

adsorptionchiralitycholesteric liquid crystalsDNA recognitionhelicenesintrinsic chiralitymolecular dynamics simulationsracemic mixturestructural selectivity

Identifiers

PMID33171884
PMCPMC7664699
OpenAlexW3095649872

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.