Evidence map›Paper›PMID 33171880›Full record

ArticleInternational journal of molecular sciences2020

The Convergence of the Hedgehog/Intein Fold in Different Protein Splicing Mechanisms.

Hannes M Beyer, Salla I Virtanen, A Sesilja Aranko, Kornelia M Mikula, George T Lountos, Alexander Wlodawer, O H Samuli Ollila, Hideo Iwaï

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. A Unique THN Motif Is Critical for Enabling Efficient C-Terminal Traceless Cleavage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Calcimycin InhibitsACS infectious diseases · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hannes M BeyerInstitute of Biotechnology, University of Helsinki, P.O. Box 65, FIN-00014 Helsinki, Finland.ORCID 0000-0002-6882-006X
Salla I VirtanenInstitute of Biotechnology, University of Helsinki, P.O. Box 65, FIN-00014 Helsinki, Finland.
A Sesilja ArankoInstitute of Biotechnology, University of Helsinki, P.O. Box 65, FIN-00014 Helsinki, Finland.
Kornelia M MikulaInstitute of Biotechnology, University of Helsinki, P.O. Box 65, FIN-00014 Helsinki, Finland.
George T LountosBasic Science Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA.ORCID 0000-0003-3463-8881
Alexander WlodawerMacromolecular Crystallography Laboratory, National Cancer Institute, Frederick, MD 21702, USA.
O H Samuli OllilaInstitute of Biotechnology, University of Helsinki, P.O. Box 65, FIN-00014 Helsinki, Finland.ORCID 0000-0002-8728-1006
Hideo IwaïInstitute of Biotechnology, University of Helsinki, P.O. Box 65, FIN-00014 Helsinki, Finland.ORCID 0000-0001-7376-5264
University of Helsinki · FIFrederick National Laboratory for Cancer Research · USNational Cancer Institute · US

Funding

Academy of Finland 277335,315596Biocenter Finland N.A.NIH HHS HHSN261200800001ENovo Nordisk Fonden NNF17OC0025402,NNF17OC0027550
6 · The paper itself

Abstract

Protein splicing catalyzed by inteins utilizes many different combinations of amino-acid types at active sites. Inteins have been classified into three classes based on their characteristic sequences. We investigated the structural basis of the protein splicing mechanism of class 3 inteins by determining crystal structures of variants of a class 3 intein from

Indexed as

Bacterial ProteinsCatalytic DomainHedgehog ProteinsInteinsMolecular Dynamics SimulationMycobacteriumProtein SplicingRNA SplicingBacterial ProteinsHedgehog Proteinsinteinproteaseprotein engineeringprotein evolutionprotein-splicing mechanism

Identifiers

PMID33171880
PMCPMC7664689
OpenAlexW3097430184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.