Evidence map›Paper›PMID 33171814›Full record

ArticleMarine drugs2020

Mitochondrial Targeting in an Anti-Austerity Approach Involving Bioactive Metabolites Isolated from the Marine-Derived Fungus

Waleed A Abdel-Naime, Atsushi Kimishima, Andi Setiawan, John Refaat Fahim, Mostafa A Fouad, Mohamed Salah Kamel, Masayoshi Arai

Abstract read
In one paragraph

Article in Marine drugs, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Bioprospecting ofFrontiers in microbiology · 2024
    Review
  7. Article
  8. Article
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Waleed A Abdel-NaimeGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.
Atsushi KimishimaGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.ORCID 0000-0002-8037-4293
Andi SetiawanDepartment of Chemistry, Faculty of Science, Lampung University, J1. Prof. Dr. Sumantri Brodjonegoro No. 1, Bandar Lampung 35145, Indonesia.
John Refaat FahimDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.ORCID 0000-0002-2425-0819
Mostafa A FouadDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Mohamed Salah KamelDepartment of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia 61519, Egypt.
Masayoshi AraiGraduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan.

Funding

Japan Agency for Medical Research and Development JP20am0101084Japan Society for the Promotion of Science 17H04645Japan Society for the Promotion of Science 18H02096Kobayashi International Scholarship Foundation N/A
6 · The paper itself

Abstract

The tumor microenvironment is a nutrient-deficient region that alters the cancer cell phenotype to aggravate cancer pathology. The ability of cancer cells to tolerate nutrient starvation is referred to as austerity. Compounds that preferentially target cancer cells growing under nutrient-deficient conditions are being employed in anti-austerity approaches in anticancer drug discovery. Therefore, in this study, we investigated physcion (

Indexed as

Antineoplastic AgentsAspergillusCell Line, TumorCell ProliferationDose-Response Relationship, DrugElectron Transport Chain Complex ProteinsEnergy MetabolismGlucoseHumansInhibitory Concentration 50MitochondriaMolecular StructurePancreatic NeoplasmsStructure-Activity RelationshipTumor MicroenvironmentAntineoplastic AgentsElectron Transport Chain Complex ProteinsGlucoseausteritycancermarine-derived Aspergillus sp.microenvironmentmitochondrial electron transport chainnutrient starvationphyscion

Identifiers

PMID33171814
PMCPMC7694948

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.