Evidence map›Paper›PMID 33171590›Full record

ArticleViruses2020

A Cell-Based ELISA to Improve the Serological Analysis of Anti-SARS-CoV-2 IgG.

Gianpaolo Zarletti, Massimo Tiberi, Veronica De Molfetta, Maurizio Bossù, Elisa Toppi, Paola Bossù, Giuseppe Scapigliati

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.3field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
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  8. An Altered Metabolism in Leukocytes ShowingFrontiers in molecular biosciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gianpaolo ZarlettiDipartimento per l'Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01000 Viterbo, Italy.ORCID 0000-0002-6666-3646
Massimo TiberiDipartimento per l'Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01000 Viterbo, Italy.ORCID 0000-0002-0121-2318
Veronica De MolfettaDipartimento per l'Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01000 Viterbo, Italy.
Maurizio BossùDepartment of Oral and Maxillofacial Science, "Sapienza" University, 00146 Roma, Italy.
Elisa ToppiIRCCS Fondazione Santa Lucia, Experimental Neuropsychobiology Lab, Via del Fosso di Fiorano 64, 00143 Roma, Italy.ORCID 0000-0001-7354-1535
Paola BossùIRCCS Fondazione Santa Lucia, Experimental Neuropsychobiology Lab, Via del Fosso di Fiorano 64, 00143 Roma, Italy.ORCID 0000-0002-1432-0078
Giuseppe ScapigliatiDipartimento per l'Innovazione Biologica, Agroalimentare e Forestale, Università della Tuscia, 01000 Viterbo, Italy.ORCID 0000-0001-9730-9394
Università degli Studi della Tuscia · ITFondazione Santa Lucia · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Knowledge of the antibody-mediated immune response to SARS-CoV-2 is crucial to understand virus immunogenicity, establish seroprevalence, and determine whether subjects or recovered patients are at risk for infection/reinfection and would therefore benefit from vaccination. Here, we describe a novel and simple cell-ELISA specifically designed to measure viral spike S1-specific IgG produced in vitro by B cells in peripheral blood mononuclear cell (PBMC) cultures from a cohort of 45 asymptomatic (

Indexed as

AdolescentAdultAgedAged, 80 and overAntibodies, ViralBetacoronavirusChildClinical Laboratory TechniquesCoronavirus InfectionsCOVID-19COVID-19 TestingEnzyme-Linked Immunosorbent AssayFemaleHumansImmunoglobulin GMaleAntibodies, ViralImmunoglobulin GSpike Glycoprotein, CoronavirusB cell memorycell-ELISACOVID-19in vitro IgGSARS-CoV-2spike S1 protein

Identifiers

PMID33171590
PMCPMC7695166
OpenAlexW3096377452

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.