Evidence map›Paper›PMID 33171535›Full record

ArticleJournal of applied toxicology : JAT2021

Long-term exposure to triclosan increases migration and invasion of human breast epithelial cells in vitro.

Abdullah Farasani, Philippa D Darbre

Open access · hybridAbstract read
In one paragraph

Article in Journal of applied toxicology : JAT, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Triclosan: A Small Molecule with Controversial Roles.Antibiotics (Basel, Switzerland) · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Abdullah FarasaniBiomedical Research Unit, Medical Research Centre, and Department of Medical Laboratory Technology, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia.
Philippa D DarbreSchool of Biological Sciences, University of Reading, Reading, UK.ORCID 0000-0002-2056-3383
Jazan University · SAUniversity of Reading · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extensive use of triclosan (2,4,4'-trichloro-2'-hydroxydiphenyl ether) as an antimicrobial agent in household and personal care products has resulted in global exposure of the human population. Its presence in human tissues, including milk, and its oestrogen-disrupting properties raise concerns for an involvement in breast cancer. Because metastatic tumour spread is the main cause of breast cancer mortality, we have investigated the effects of triclosan on cell migration and invasion using three human breast epithelial cell lines and using concentrations comparable with those in human tissues. Long-term exposure to 10

Indexed as

Antigens, CDAnti-Infective Agents, LocalCadherinsCell Line, TumorCell MovementCell ProliferationEpithelial CellsEpithelial-Mesenchymal TransitionEstrogensGene Expression Regulation, NeoplasticHumansMCF-7 CellsNeoplasm InvasivenessRNA, MessengerTriclosanAntigens, CDAnti-Infective Agents, LocalCadherinsCDH1 protein, humanEstrogensRNA, MessengerTriclosanbreast cancerE-cadherininvasionmigrationmotilitytriclosanxCELLigence

Identifiers

PMID33171535
PMCPMC8246770
OpenAlexW3104045483

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.