Evidence map›Paper›PMID 33171307›Full record

ArticleMolecular metabolism2021

FGF15/19 is required for adipose tissue plasticity in response to thermogenic adaptations.

Samantha Morón-Ros, Iker Uriarte, Carmen Berasain, Matías A Avila, Mònica Sabater-Masdeu, José María Moreno-Navarrete, José Manuel Fernández-Real, Marta Giralt, Francesc Villarroya, Aleix Gavaldà-Navarro

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 35 citations in OpenAlex.

  1. Review
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  4. Frontiers in microbiology · 2026
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  6. FGF-based drug discovery: advances and challenges.Nature reviews. Drug discovery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Samantha Morón-RosDepartment of Biochemistry and Molecular Biomedicine and Institute of Biomedicine, University of Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; CIBEROBN, Carlos III Health Institute, Spain.
Iker UriarteHepatology Program, CIMA, University of Navarra, IdiSNA, Pamplona, Spain; CIBEREHD, Carlos III Health Institute, Spain.
Carmen BerasainHepatology Program, CIMA, University of Navarra, IdiSNA, Pamplona, Spain; CIBEREHD, Carlos III Health Institute, Spain.
Matías A AvilaHepatology Program, CIMA, University of Navarra, IdiSNA, Pamplona, Spain; CIBEREHD, Carlos III Health Institute, Spain.
Mònica Sabater-MasdeuCIBEROBN, Carlos III Health Institute, Spain; Department of Diabetes, Endocrinology and Nutrition, de Girona Biomedical Research Institute (IdIBGi), Girona, Spain.
José María Moreno-NavarreteCIBEROBN, Carlos III Health Institute, Spain; Department of Diabetes, Endocrinology and Nutrition, de Girona Biomedical Research Institute (IdIBGi), Girona, Spain.
José Manuel Fernández-RealCIBEROBN, Carlos III Health Institute, Spain; Department of Diabetes, Endocrinology and Nutrition, de Girona Biomedical Research Institute (IdIBGi), Girona, Spain.
Marta GiraltDepartment of Biochemistry and Molecular Biomedicine and Institute of Biomedicine, University of Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; CIBEROBN, Carlos III Health Institute, Spain.
Francesc VillarroyaDepartment of Biochemistry and Molecular Biomedicine and Institute of Biomedicine, University of Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; CIBEROBN, Carlos III Health Institute, Spain. Electronic address: fvillarroya@ub.edu.
Aleix Gavaldà-NavarroDepartment of Biochemistry and Molecular Biomedicine and Institute of Biomedicine, University of Barcelona, Institut de Recerca Sant Joan de Déu, Esplugues de Llobregat, Barcelona, Spain; CIBEROBN, Carlos III Health Institute, Spain. Electronic address: aleixgavalda@ub.edu.
Instituto de Salud Carlos III · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine the role of enterokine FGF15/19 in adipose tissue thermogenic adaptations.

methodsCirculating FGF19 and gene expression (qRT-PCR) levels were assessed in subcutaneous adipose tissue from obese human patients. Effects of experimentally increased FGF15 and FGF19 levels in vivo were determined in mice using adenoviral and adeno-associated vectors. Adipose tissues were characterized in FGF15-null mice under distinct cold-related thermogenic challenges. The analyses spanned metabolic profiling, tissue characterization, histology, gene expression, and immunoblot assays.

resultsIn humans, FGF19 levels are directly associated with UCP1 gene expression in subcutaneous adipose tissue. Experimental increases in FGF15 or FGF19 induced white fat browning in mice as demonstrated by the appearance of multilocular beige cells and markers indicative of a beige phenotype, including increased UCP1 protein levels. Mice lacking FGF15 showed markedly impaired white adipose tissue browning and a mild reduction in parameters indicative of BAT activity in response to cold-induced environmental thermogenic challenges. This was concomitant with signs of altered systemic metabolism, such as reduced glucose tolerance and impaired cold-induced insulin sensitization.

conclusionsEnterokine FGF15/19 is a key factor required for adipose tissue plasticity in response to thermogenic adaptations.

Indexed as

Adipose TissueAdipose Tissue, BrownAdipose Tissue, WhiteAnimalsFemaleFibroblast Growth FactorsHumansInsulinInsulin ResistanceMaleMiceMice, Inbred C57BLMice, KnockoutObesityThermogenesisUncoupling Protein 1FGF19 protein, humanfibroblast growth factor 15, mouseFibroblast Growth FactorsInsulinUncoupling Protein 1Adipose tissue plasticityBrowningEnterokineFibroblast Growth Factor 15Fibroblast Growth Factor 19

Identifiers

PMID33171307
PMCPMC7691747
OpenAlexW3096346442

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.