Observational studyAnaesthesia, critical care & pain medicine2021
Association between red blood cell distribution width and mortality of COVID-19 patients.
Observational study in Anaesthesia, critical care & pain medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.
What it found
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Who cites it
37 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Role of red blood cell distribution width, as a prognostic indicator in COVID-19: A systematic review and meta-analysis.Reviews in medical virology · 2022Pooled it
- Factors associated with mortality in patients with COVID-19 admitted to intensive care: a systematic review and meta-analysis.Anaesthesia · 2021Pooled it
- B-Type Natriuretic Peptide Concentrations, COVID-19 Severity, and Mortality: A Systematic Review and Meta-Analysis With Meta-Regression.Frontiers in cardiovascular medicine · 2021Pooled it
- Prognostic value and nonlinear association of the rdw/albumin ratio with mortality among COVID-19 patients: a MIMIC-IV database analysis.BMC infectious diseases · 2026Article
- Association between the red cell distribution width-to-platelet ratio and 30-day all-cause mortality among patients with acute respiratory failure: a retrospective analysis of the MIMIC-IV database.BMC pulmonary medicine · 2025Article
- A Retrospective Analysis of the Predictive Role of RDW, MPV, and MPV/PLT Values in 28-Day Mortality of Geriatric Sepsis Patients: Associations with APACHE II and SAPS II Scores.Medicina (Kaunas, Lithuania) · 2025Article
- Associations between age, red cell distribution width and 180-day and 1-year mortality in giant cell arteritis patients: mediation analyses and machine learning in a cohort study.Arthritis research & therapy · 2025Article
- Under the background of the new global definition of ARDS: an interpretable machine learning approach for predicting 28-day ICU mortality in patients with sepsis complicated by ARDS.Frontiers in physiology · 2025Article
- Prediction of the need for surgery in patients with unruptured abdominal aortic aneurysm based on SOFA score.PloS one · 2025Article
- Prognostic value of red blood cell distribution width in sepsis induced cardiomyopathy patients.Scientific reports · 2024Article
- Pre-hospital oxygen therapy and saturation variability in COVID-19 patients with and without glucose metabolism disorders: part of the COLOS Study.Scientific reports · 2024Article
- Increased red cell distribution width predicts mortality in COVID-19 patients admitted to a Dutch intensive care unit.Acute and critical care · 2024Article
- Relationship between initial red cell distribution width and ΔRDW and mortality in cardiac arrest patients.ESC heart failure · 2024Article
- Clinical value of the red blood cell distribution width to albumin ratio in the assessment of prognosis in critically ill patients with sepsis: a retrospective analysis.Journal of thoracic disease · 2024Article
- Feature selection and risk prediction for diabetic patients with ketoacidosis based on MIMIC-IV.Frontiers in endocrinology · 2024Article
- Red Blood Cell Distribution Width Predicts Mortality in Hospitalized Patients with Severe Fever with Thrombocytopenia Syndrome.Journal of inflammation research · 2024Article
- Red cell distribution width and mortality in older patients with frailty in the emergency department.BMC emergency medicine · 2023Article
- Elevated Red Blood Cell Distribution Width Is Associated with Poor Prognosis in Fractured Patients Admitted to Intensive Care Units.Orthopaedic surgery · 2023Article
- Association between Red Blood Cell Distribution Width and Short-Term Mortality in Patients with Paralytic Intestinal Obstruction: Retrospective Data Analysis Based on the MIMIC-III Database.Emergency medicine international · 2023Article
- Development and validation of a clinical score combining the sequential organ failure assessment score with inflammation-based markers to predict outcome of patients with sepsis.American journal of translational research · 2023Article
Corrections and comments
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Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe have previously reported an association between high red blood cell distribution width (RDW) and mortality in septic and brain infarction patients. However, no association between RDW and mortality in coronavirus disease 2019 (COVID-19) patients has been reported so far; thus, the objective of this study was to determine if that association exists.
methodsProspective and observational study carried out in 8 Intensive Care Units from 6 hospitals of Canary Islands (Spain) including COVID-19 patients. We recorded RDW at ICU admission and 30-day survival.
resultsWe found that patients who did not survive (n=25) compared to surviving patients (n=118) were older (p=0.004), showed higher RDW (p=0.001), urea (p<0.001), APACHE-II (p<0.001) and SOFA (p<0.001), and lower platelet count (p=0.007) and pH (p=0.008). Multiple binomial logistic regression analysis showed that RDW was associated with 30-day mortality after controlling for: SOFA and age (OR=1.659; 95% CI=1.130-2.434; p=0.01); APACHE-II and platelet count (OR=2.062; 95% CI=1.359-3.129; p=0.001); and pH and urea (OR=1.797; 95% CI=1.250-2.582; p=0.002). The area under the curve (AUC) of RDW for mortality prediction was of 71% (95% CI=63-78%; p<0.001). We did not find significant differences in the predictive capacity between RDW and SOFA (p=0.66) or between RDW and APACHE-II (p=0.12).
conclusionsOur study provides new information regarding the ability to predict mortality in patients with COVID-19. There is an association between high RDW and mortality. RDW has a good performance to predict 30-day mortality, similar to other severity scores (such as APACHE II and SOFA) but easier and faster to obtain.
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