Evidence map›Paper›PMID 33171153›Full record

ArticleBrain research2021

Factors regulating serine racemase and d-amino acid oxidase expression in the mouse striatum.

Shunsuke Takagi, Darrick T Balu, Joseph T Coyle

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. D-Amino Acids as a Biomarker in Schizophrenia.Diseases (Basel, Switzerland) · 2022
    Review
  3. Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy.Frontiers in molecular neuroscience · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Shunsuke TakagiDepartment of Psychiatry and Behavioral Sciences, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA. Electronic address: stakagi.psyc@tmd.ac.jp.
Darrick T BaluDepartment of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA.
Joseph T CoyleDepartment of Psychiatry, Harvard Medical School, Boston, MA 02115, USA; Laboratory for Psychiatric and Molecular Neuroscience, McLean Hospital, Belmont, MA 02478, USA.
Harvard University · USTokyo Medical and Dental University · JP

Funding

PSYCHOSIS AND BRAIN GLUTAMATER01MH051290 · NIMH · MC LEAN HOSPITAL (BELMONT, MA) · PI COYLE, JOSEPH T. · 1994 to 2017
$5.0M
NMDA receptor hypofunction contributes to the dendritic dysplasia in schizophreniR00MH099252 · NIMH · MCLEAN HOSPITAL · PI BALU, DARRICK T · 2015 to 2017
$726k
NMDA receptor hypofunction contributes to the dendritic dysplasia in schizophreniK99MH099252 · NIMH · MCLEAN HOSPITAL · PI BALU, DARRICK T · 2013 to 2014
$230k
NIMH NIH HHS K99 MH099252NIMH NIH HHS R00 MH099252NIMH NIH HHS R01 MH051290
6 · The paper itself

Abstract

d-Serine plays an important role in modulating N-methyl-d-aspartate receptor (NMDAR) neurotransmission in the mammalian brain by binding to the receptor's glycine modulatory site (GMS). The cytosolic enzyme serine racemase (SR) converts L-serine to d-serine, while the peroxisomal enzyme d-amino acid oxidase (DAAO) catalyzes the breakdown of d-serine. Although it is important to understand how the activities of SR and DAAO regulate d-serine levels, very little is known about the mechanisms that regulate the expression of SR and DAAO. In this study, we investigated whether the different centrally active drugs affect the expression of SR and DAAO in adult mouse brain. We found that the NMDAR antagonist, MK801, and cocaine, psychotropic drugs that both augment glutamate release, reduce the expression of SR and DAAO. This regulation is brain region selective, and in the case of cocaine, is reversed in part byα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) antagonist 2,3-dihydroxy-6-nitro-7-sulfamoyl-benzo[f]quinoxaline-2,3-dione (NBQX). However, d-serine and antipsychotics do not regulate SR and DAAO protein levels. In a genetic model of SR disruption, we found that DAAO expression was unaltered in SR conditional knockout mice, in which tissue d-serine content remains fairly stable despite marked reduction in SR expression. This study reveals a new mechanism by which AMPAR activity could regulate NMDAR function via d-serine availability.

Indexed as

AnimalsBrainCocaineCorpus StriatumD-Amino-Acid OxidaseDizocilpine MaleateFemaleGene ExpressionGene Expression RegulationMaleMiceMice, Inbred C57BLMice, KnockoutQuinoxalinesRacemases and EpimerasesReceptors, AMPA2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxalineCocaineD-Amino-Acid OxidaseDao1 protein, mouseDizocilpine MaleateQuinoxalinesRacemases and EpimerasesReceptors, AMPAReceptors, N-Methyl-D-AspartateSerineSerine RacemaseAMPA receptorClozapineCocaineMK801NMDA receptorSerine racemase

Identifiers

PMID33171153
PMCPMC8753929
OpenAlexW3096837893

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.