ArticleJournal of the Royal Society, Interface2020
Surface periarterial spaces of the mouse brain are open, not porous.
Article in Journal of the Royal Society, Interface, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- High frame ratebioRxiv : the preprint server for biology · 2026Article
- MR-AIV reveals in vivo brain-wide fluid flow with physics-informed AI.Science advances · 2026Article
- Robust MR-AIV: A Systematic Study of Robustness Improvement and Sensitivity Analysis of MR-AIV.bioRxiv : the preprint server for biology · 2026Article
- Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.Fluids and barriers of the CNS · 2026Article
- MR-AIV revealsbioRxiv : the preprint server for biology · 2025Article
- Perivascular interactions and tissue properties modulate directional glymphatic transport in the brain.Fluids and barriers of the CNS · 2025Article
- A review of cerebrospinal fluid circulation with respect to Chiari-like malformation and syringomyelia in brachycephalic dogs.Fluids and barriers of the CNS · 2025Review
- Directional flow in perivascular networks: mixed finite elements for reduced-dimensional models on graphs.Journal of mathematical biology · 2024Article
- Regulation of brain fluid volumes and pressures: basic principles, intracranial hypertension, ventriculomegaly and hydrocephalus.Fluids and barriers of the CNS · 2024Review
- Astrocytes sense glymphatic-level shear stress through the interaction of sphingosine-1-phosphate with Piezo1.iScience · 2024Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Fluids and barriers of the CNS · 2024Article
- Article
- Hydraulic resistance of three-dimensional pial perivascular spaces in the brain.Research square · 2023Article
- Perivascular pumping of cerebrospinal fluid in the brain with a valve mechanism.Journal of the Royal Society, Interface · 2023Article
- Quantifying the relationship between spreading depolarization and perivascular cerebrospinal fluid flow.Scientific reports · 2023Article
- Sizes and shapes of perivascular spaces surrounding murine pial arteries.Fluids and barriers of the CNS · 2023Article
- Artificial intelligence velocimetry reveals in vivo flow rates, pressure gradients, and shear stresses in murine perivascular flows.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cerebrospinal Fluid Flow.Annual review of fluid mechanics · 2023Article
- Transport in the Brain Extracellular Space: Diffusion, but Which Kind?International journal of molecular sciences · 2022Review
- The glymphatic system: Current understanding and modeling.iScience · 2022Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Fluid-dynamic models of the flow of cerebrospinal fluid in the brain have treated the perivascular spaces either as open (without internal solid obstacles) or as porous. Here, we present experimental evidence that pial (surface) periarterial spaces in mice are essentially open. (1) Paths of particles in the perivascular spaces are smooth, as expected for viscous flow in an open vessel, not diffusive, as expected for flow in a porous medium. (2) Time-averaged velocity profiles in periarterial spaces agree closely with theoretical profiles for viscous flow in realistic models, but not with the nearly uniform profiles expected for porous medium. Because these spaces are open, they have much lower hydraulic resistance than if they were porous. To demonstrate, we compute hydraulic resistance for realistic periarterial spaces, both open and porous, and show that the resistance of the porous spaces are greater, typically by a factor of a hundred or more. The open nature of these periarterial spaces allows significantly greater flow rates and more efficient removal of metabolic waste products.
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