Evidence map›Paper›PMID 33170971›Full record

ArticleThe European journal of neuroscience2021

Responsivity to light in familial hemiplegic migraine type 1 mutant mice reveals frequency-dependent enhancement of visual network excitability.

Matthijs J L Perenboom, Maarten Schenke, Michel D Ferrari, Gisela M Terwindt, Arn M J M van den Maagdenberg, Else A Tolner

Open access · hybridAbstract read
In one paragraph

Article in The European journal of neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Hemiplegic migraine: genetics and pathophysiology.The Journal of clinical investigation · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Matthijs J L PerenboomDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-3849-6975
Maarten SchenkeDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Michel D FerrariDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.
Gisela M TerwindtDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-3140-6882
Arn M J M van den MaagdenbergDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-9310-5535
Else A TolnerDepartment of Neurology, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0002-6501-9971
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Migraine patients often report (inter)ictal hypersensitivity to light, but the underlying mechanisms remain an enigma. Both hypo- and hyperresponsivity of the visual network have been reported, which may reflect either intra-individual dynamics of the network or large inter-individual variation in the measurement of human visual evoked potential data. Therefore, we studied visual system responsivity in freely behaving mice using combined epidural electroencephalography and intracortical multi-unit activity to reduce variation in recordings and gain insight into visual cortex dynamics. For better clinical translation, we investigated transgenic mice that carry the human pathogenic R192Q missense mutation in the α

Indexed as

Migraine with AuraAnimalsCalcium Channels, N-TypeDisease Models, AnimalEvoked Potentials, VisualHumansMiceMice, TransgenicCalcium Channels, N-TypeCaV2.1 calcium channelselectrophysiologysensory systemsvisual stimulation

Identifiers

PMID33170971
PMCPMC8048865
OpenAlexW3099676356

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.