Evidence map›Paper›PMID 33170669›Full record

ReviewChemical reviews2021

Transporters Involved in the Biogenesis and Functionalization of the Mycobacterial Cell Envelope.

Mary Jackson, Casey M Stevens, Lei Zhang, Helen I Zgurskaya, Michael Niederweis

Open access · greenAbstract readReview
In one paragraph

Review in Chemical reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Optimizing a Subunit Vaccine ofIranian journal of public health · 2025
    Article
  9. Article
  10. Effective killing ofMicrobiology spectrum · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Three-component systems represent a common pathway for extracytoplasmic addition of pentofuranose sugars into bacterial glycans.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. The C-terminus is essential for the stability of the mycobacterial channel protein MspA.Protein science : a publication of the Protein Society · 2024
    Article
  18. Article
  19. Article
  20. Foods (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Mary JacksonMycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523-1682, United States.ORCID 0000-0002-9212-0258
Casey M StevensDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.
Lei ZhangDepartment of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294, United States.ORCID 0000-0002-8566-6068
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma, 101 Stephenson Parkway, Norman, Oklahoma 73019, United States.ORCID 0000-0001-8929-4727
Michael NiederweisDepartment of Microbiology, University of Alabama at Birmingham, 845 19th Street South, Birmingham, Alabama 35294, United States.
University of Alabama at Birmingham · USUniversity of Oklahoma · USColorado State University · US

Funding

Biogenesis of Lipoarabinomannan in MycobacteriaR01AI064798 · NIAID · COLORADO STATE UNIVERSITY-FORT COLLINS · PI JACKSON, MARY · 2005 to 2019
$5.4M
MmpL3 as a target for novel anti-TB agentsR01AI116525 · NIAID · COLORADO STATE UNIVERSITY · PI JACKSON, MARY · 2015 to 2024
$5.3M
Heme and hemoglobin utilization by Mycobacterium tuberculosisR01AI137338 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NIEDERWEIS, MICHAEL · 2019 to 2023
$3.3M
The necrosis-inducing toxin of Mycobacterium tuberculosisR01AI121354 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NIEDERWEIS, MICHAEL · 2016 to 2020
$2.5M
Siderophore-dependent inhibitors of Mycobacterium tuberculosisR21AI153981 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NIEDERWEIS, MICHAEL · 2020 to 2021
$445k
NIAID NIH HHS R01 AI064798NIAID NIH HHS R01 AI116525NIAID NIH HHS R01 AI121354NIAID NIH HHS R01 AI137338NIAID NIH HHS R21 AI153981
6 · The paper itself

Abstract

The biology of mycobacteria is dominated by a complex cell envelope of unique composition and structure and of exceptionally low permeability. This cell envelope is the basis of many of the pathogenic features of mycobacteria and the site of susceptibility and resistance to many antibiotics and host defense mechanisms. This review is focused on the transporters that assemble and functionalize this complex structure. It highlights both the progress and the limits of our understanding of how (lipo)polysaccharides, (glyco)lipids, and other bacterial secretion products are translocated across the different layers of the cell envelope to their final extra-cytoplasmic location. It further describes some of the unique strategies evolved by mycobacteria to import nutrients and other products through this highly impermeable barrier.

Indexed as

Cell MembraneCell WallMembrane LipidsMembrane Transport ProteinsMycobacteriumOrganelle BiogenesisMembrane LipidsMembrane Transport Proteins

Identifiers

PMID33170669
PMCPMC8107195
OpenAlexW3104671066

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.