ArticleHuman brain mapping2021
Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.
Article in Human brain mapping, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Automated Segmentation of Brainstem and Subcortical White Matter: Mapping the Deep Tegmental Core with BundleParc.bioRxiv : the preprint server for biology · 2026Article
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- Knowledge, mechanisms, and intervention of the polytrauma clinical triad in military pain medicine.The Korean journal of pain · 2025Review
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- The cingulum: a central hotspot for the battle against chronic intractable pain?Brain communications · 2024Review
- The role of the brainstem in sleep disturbances and chronic pain of Gulf War and Iraq/Afghanistan veterans.Frontiers in molecular neuroscience · 2023Article
- Brainstem Diffusion Tensor Tractography and Clinical Applications in Pain.Frontiers in pain research (Lausanne, Switzerland) · 2022Review
- Combining Regional and Connectivity Metrics of Functional Magnetic Resonance Imaging and Diffusion Tensor Imaging for Individualized Prediction of Pain Sensitivity.Frontiers in molecular neuroscience · 2022Article
- Brainstem damage is associated with poorer sleep quality and increased pain in gulf war illness veterans.Life sciences · 2021Article
- Microstructural alterations in medial forebrain bundle are associated with interindividual pain sensitivity.Human brain mapping · 2021Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The perception of pain to noxious stimuli, also known as pain sensitivity, varies among individuals. The comprised brain structures and their white matter pathways are complex and elusive. Here, we aimed to investigate whether variation of microstructure of the medial forebrain bundle (MFB), a tract connecting the basal forebrain with the brain stem, is associated with interindividual pain sensitivity. We assessed interindividual pain sensitivity as a rating of pain intensity to heat stimuli (45, 47, and 48.9°C) in 38 healthy men (age: 27.05 ± 5.7 years). We also reconstructed the MFB using multitensor tractography from diffusion magnetic resonance imaging (dMRI) and calculated free-water corrected dMRI measures of fractional anisotropy (FA
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.