ArticleThe Laryngoscope2021
Socioeconomic Status Drives Racial Disparities in HPV-negative Head and Neck Cancer Outcomes.
Article in The Laryngoscope, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Disparities in Survival of Head and Neck Cancer in the Hispanic Population: Systematic-Review and Meta-analysis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2025Pooled it
- Socioeconomic Disadvantage and Care Proximity Influence Stage at Presentation in Head and Neck Cancer.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026Article
- Impact of neighbor-level disadvantage on survival outcomes in head and neck squamous cell carcinoma.Cancer causes & control : CCC · 2025Article
- Demographic Disparities in Diagnosis and Treatment of Anxiety and Depressive Disorders in Head and Neck Cancer Survivors.Head & neck · 2025Article
- Disparities in Care for Patients with Head and Neck Cancer.Surgical oncology clinics of North America · 2024Review
- Partly linear single-index cure models with a nonparametric incidence link function.Statistical methods in medical research · 2024Article
- Association between cardiovascular health and human papillomavirus infection: analysis from NHANES 2005-2016.Frontiers in public health · 2024Article
- Examining the effect of Medicaid expansion on early detection of head and neck cancer of the oral cavity and pharynx by HPV-type and generosity of dental benefits.Cancer reports (Hoboken, N.J.) · 2023Article
- Racial survival disparities in head and neck cancer clinical trials.Journal of the National Cancer Institute · 2023Article
- Investigating miR-9 as a mediator in laryngeal cancer health disparities.Frontiers in oncology · 2023Article
- Treatment selection towards active surveillance over definitive treatment for pituitary adenomas is influenced by sociodemographic factors.Clinical neurology and neurosurgery · 2022Article
- Chronic stress promotes an immunologic inflammatory state and head and neck cancer growth in a humanized murine model.Head & neck · 2022Article
- Prognostic impact of socioeconomic status compared to overall stage for HPV-negative head and neck squamous cell carcinoma.Oral oncology · 2021Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectives/hypothesisTo determine drivers of the racial disparity in stage at diagnosis and overall survival (OS) between black and white patients with HPV-negative head and neck squamous cell carcinoma (HNSCC). STUDY
designRetrospective cohort study.
methodsData were examined from of a population-based HNSCC study in North Carolina. Multivariable logistic regression and Cox proportional hazards models were used to assess racial disparities in stage at diagnosis and OS with sequential adjustment sets.
resultsA total of 340 black patients and 864 white patients diagnosed with HPV-negative HNSCC were included. In the unadjusted model, black patients had increased odds of advanced T stage at diagnosis (OR 2.0; 95% CI [1.5-2.5]) and worse OS (HR 1.3, 95% CI 1.1-1.6) compared to white patients. After adjusting for age, sex, tumor site, tobacco use, and alcohol use, the racial disparity persisted for advanced T-stage at diagnosis (OR 1.7; 95% CI [1.3-2.3]) and showed a non-significant trend for worse OS (HR 1.1, 95% CI 0.9-1.3). After adding SES to the adjustment set, the association between race and stage at diagnosis was lost (OR: 1.0; 95% CI [0.8-1.5]). Further, black patients had slightly favorable OS compared to white patients (HR 0.8, 95% CI [0.6-1.0]; P = .024).
conclusionsSES has an important contribution to the racial disparity in stage at diagnosis and OS for HPV-negative HNSCC. Low SES can serve as a target for interventions aimed at mitigating the racial disparities in head and neck cancer. LEVEL OF EVIDENCE: 4 Laryngoscope, 131:1301-1309, 2021.
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Registered trials
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