ArticleBioprocess and biosystems engineering2021
Improvement of stilbene production by mulberry Morus alba root culture via precursor feeding and co-elicitation.
Article in Bioprocess and biosystems engineering, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Research progress of endophytes and their secondary metabolites inPlant signaling & behavior · 2026Review
- Integrated multi-omics analyses reveal that p-coumaroyl-CoA 2'-hydroxylases act upstream of stilbene synthases to mediate oxyresveratrol biosynthesis in mulberry (Morus alba).Plant communications · 2026Article
- A review on Mitragyna alkaloids pharmacology, biosynthesis and biotechnological insights.Journal, genetic engineering & biotechnology · 2026Review
- Modulating stilbenes in peanut cells: a novel approach with metabolic modulators.Plant cell reports · 2025Article
- Article
- Improvement in the Biosynthesis of Antioxidant-Active Metabolites in In Vitro Cultures ofAntioxidants (Basel, Switzerland) · 2023Article
- Biotechnological Approach to Increase Oxyresveratrol Production in Mulberry In Vitro Plants under Elicitation.Plants (Basel, Switzerland) · 2023Article
- Characteristics of Soil Physicochemical Properties and Microbial Community of Mulberry (Microorganisms · 2023Article
- Elicitation of Stilbenes and Benzofuran Derivatives in Hairy Root Cultures of White Mulberry (Plants (Basel, Switzerland) · 2022Article
- Article
- In vitro bioproduction and enhancement of moscatilin from a threatened tropical epiphytic orchid,3 Biotech · 2021Article
- Review
- Oxyresveratrol: Sources, Productions, Biological Activities, Pharmacokinetics, and Delivery Systems.Molecules (Basel, Switzerland) · 2021Review
- Impact of Environmental Factors on Stilbene Biosynthesis.Plants (Basel, Switzerland) · 2021Review
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Authors and funding
7 authors at 4 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Large amounts of Morus alba L. (MA) roots are needed as the source of active stilbenes in the industrial production of traditional medicines and cosmeceuticals. A recent investigation demonstrated resveratrol and its derivatives to be promising anti-COVID-19 agents. However, conventional cultivation of MA does not meet the demand for its stilbenes, and root quality usually varies between crops. This study established the in vitro non-GMO root culture of MA and optimized the root density, precursor feeding, and elicitors for stilbene productivity. A root culture with optimal inoculum density (3 g/flask of 30 mL medium) accumulated mulberroside A, oxyresveratrol, and resveratrol at 18.7 ± 1.00 mg/g, 136 ± 5.05 µg/g, and 41.6 ± 5.84 µg/g dry weight (DW), respectively. The feeding of L-tyrosine shortened the time required to reach the stilbene productive stage. Root cultures co-treated with 200 µM methyl jasmonate and 2 mg/mL yeast extract accumulated the highest contents of mulberroside A (30.3 ± 2.68 mg/g DW), oxyresveratrol (68.6 ± 3.53 µg/g DW), and resveratrol (10.2 ± 0.53 µg/g DW). In summary, root culture is a promising and sustainable source of stilbenes for the development of health products and agents for further investigation as potential anti-COVID-19 agents.
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