Evidence map›Paper›PMID 33170333›Full record

ArticleWiener klinische Wochenschrift2020

Structured ICU resource management in a pandemic is associated with favorable outcome in critically ill COVID‑19 patients.

Sebastian J Klein, Romuald Bellmann, Hannes Dejaco, Stephan Eschertzhuber, Dietmar Fries, Wilhelm Furtwängler, Lukas Gasteiger, Walter Hasibeder, Raimund Helbok, Christoph Hochhold and 15 more

Abstract read
In one paragraph

Article in Wiener klinische Wochenschrift, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Article
  9. [Acute kidney injury and COVID-19: lung-kidney crosstalk during severe inflammation].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2022
    Review
  10. Intensive Care Unit Equity and Regionalization in the COVID-19 Era.Annals of the American Thoracic Society · 2022
    Article
  11. Article
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  13. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Sebastian J KleinDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Romuald BellmannDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Hannes DejacoDepartment of Anesthesia and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Stephan EschertzhuberDepartment of Anesthesia and Intensive Care Medicine, Hospital Hall, Hall, Austria.
Dietmar FriesDepartment of General and Surgical Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Wilhelm FurtwänglerDepartment of Anesthesia and Intensive Care Medicine, Hospital Kufstein, Kufstein, Austria.
Lukas GasteigerDepartment of Anesthesia and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Walter HasibederDepartment of Anesthesiology and Critical Care Medicine, Hospital St. Vinzenz Zams, Zams, Austria.
Raimund HelbokDepartment of Neurology, Medical University Innsbruck, Innsbruck, Austria.
Christoph HochholdDepartment of General and Surgical Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Stefanie HoferDepartment of Internal Medicine, Hospital Hall, Hall, Austria.
Lukas KirchmairDepartment of Anesthesia and Critical Care Medicine, Hospital Schwaz, Schwaz, Austria.
Christoph KrismerDepartment of Internal Medicine, Hospital St. Vinzenz Zams, Zams, Austria.
Eugen LadnerDepartment of Anesthesia and Intensive Care Medicine, Hospital Reutte, Reutte, Austria.
Georg F LehnerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Simon MathisDepartment of Anesthesia and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Andreas MayrDepartment of Anesthesia and Intensive Care Medicine, Hospital Lienz, Lienz, Austria.
Markus MittermayrDepartment of Anesthesia and Critical Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Andreas PeerDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Christian Preuß HernándezDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
Bruno ReitterDepartment of Anesthesia and Intensive Care Medicine, Hospital St. Johann in Tyrol, St. Johann in Tyrol, Austria.
Mathias StröhleDepartment of General and Surgical Intensive Care Medicine, Medical University Innsbruck, Innsbruck, Austria.
Michael SwobodaDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
Claudius ThoméDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
Michael JoannidisDivision of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria. michael.joannidis@i-med.ac.at.ORCID http://orcid.org/0000-0002-6996-0881

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOn February 25, 2020, the first 2 patients were tested positive for severe acute respiratory syndrome coronavirus‑2 (SARS-CoV-2) in Tyrol, Austria. Rapid measures were taken to ensure adequate intensive care unit (ICU) preparedness for a surge of critically ill coronavirus disease-2019 (COVID-19) patients.

methodsThis cohort study included all COVID-19 patients admitted to an ICU with confirmed or strongly suspected COVID-19 in the State of Tyrol, Austria. Patients were recorded in the Tyrolean COVID-19 intensive care registry. Date of final follow-up was July 17, 2020.

resultsA total of 106 critically ill patients with COVID-19 were admitted to 1 of 13 ICUs in Tyrol from March 9 to July 17, 2020. Median age was 64 years (interquartile range, IQR 54-74 years) and the majority of patients were male (76 patients, 71.7%). Median simplified acute physiology score III (SAPS III) was 56 points (IQR 49-64 points). The median duration from appearance of first symptoms to ICU admission was 8 days (IQR 5-11 days). Invasive mechanical ventilation was required in 72 patients (67.9%) and 6 patients (5.6%) required extracorporeal membrane oxygenation treatment. Renal replacement therapy was necessary in 21 patients (19.8%). Median ICU length of stay (LOS) was 18 days (IQR 5-31 days), median hospital LOS was 27 days (IQR 13-49 days). The ICU mortality was 21.7% (23 patients), hospital mortality was 22.6%. There was no significant difference in ICU mortality in patients receiving invasive mechanical ventilation and in those not receiving it (18.1% vs. 29.4%, p = 0.284). As of July 17th, 2020, two patients are still hospitalized, one in an ICU, one on a general ward.

conclusionCritically ill COVID-19 patients in Tyrol showed high severity of disease often requiring complex treatment with increased lengths of ICU and hospital stay. Nevertheless, the mortality was found to be remarkably low, which may be attributed to our adaptive surge response providing sufficient ICU resources.

Indexed as

BetacoronavirusCoronavirus InfectionsPandemicsPneumonia, ViralAgedAustriaCohort StudiesCOVID-19Critical IllnessFemaleHumansIntensive Care UnitsMaleMiddle AgedSARS-CoV-2Treatment OutcomeAcute kidney injuryComorbidityExtracorporeal membrane oxygenationInvasive mechanical ventilationSARS-CoV‑2

Identifiers

PMID33170333
PMCPMC7653454

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.