ArticleInternational journal of geriatric psychiatry2021
Cognitive variability, brain aging, and cognitive decline in late-life major depression.
Article in International journal of geriatric psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Relationship Between Sarcopenia and the Trajectories of Depressive Symptoms Among Chinese Older Adults: The Mediating Effect of Social Participation.International journal of behavioral medicine · 2026Article
- Associations of Nutritional Health Risk With Cognitive Function in Older Korean Adults: The Mediating Roles of Lower Body Strength and Depression.Geriatrics & gerontology international · 2025Article
- Self-perceived cognitive fluctuations and their relationship to everyday functioning in older adults with and without HIV disease.The Clinical neuropsychologist · 2024Article
- Recent Advances in Neuropsychological Test Interpretation for Clinical Practice.Neuropsychology review · 2024Review
- Presence of Depression Is Associated with Functional Impairment in Middle-Aged and Elderly Chinese Adults with Vascular Disease/Diabetes Mellitus-A Cross-Sectional Study.International journal of environmental research and public health · 2023Article
- Intraindividual Cognitive Variability and Magnetic Resonance Imaging in Aging American Indians: Data from the Strong Heart Study.Journal of Alzheimer's disease : JAD · 2023Article
- Pathomechanisms of Vascular Depression in Older Adults.International journal of molecular sciences · 2021Review
- Predicting conversion to Alzheimer's disease among individual high-risk patients using the Characterizing AD Risk Events index model.CNS neuroscience & therapeutics · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesOlder adults with late-life major depression (LLMD) are at increased risk of dementia. Dispersion, or within-person performance variability across cognitive tests, is a potential marker of cognitive decline. This study examined group differences in dispersion between LLMD and nondepressed healthy controls (HC) and investigated whether dispersion was a predictor of cognitive performance 1 year later in LLMD. We also explored demographic, clinical, and structural imaging correlates of dispersion in LLMD and HC. We hypothesized that dispersion would be greater in LLMD compared with HC and would be associated with worse cognitive performance 1 year later in LLMD.
designParticipants were enrolled in the Neurobiology of Late-Life Depression, a naturalistic longitudinal investigation of the predictors of poor illness course in LLMD.
participantsThe baseline sample consisted of 121 older adults with LLMD and 39 HC; of these subjects, 94 LLMD and 35 HC underwent magnetic resonance imaging (MRI). One-year cognitive data were available for 107 LLMD patients. MEASUREMENTS: All participants underwent detailed clinical and structural MRI at baseline. LLMD participants also completed a comprehensive cognitive evaluation 1 year later.
resultsHigher test dispersion was evident in LLMD when compared with nondepressed controls. Greater baseline dispersion predicted 1-year cognitive decline in LLMD patients even when controlling for baseline cognitive functioning and demographic and clinical confounders. Dispersion was correlated with white matter lesions in LLMD but not HC. Dispersion was also correlated with anxiety in both LLMD and HC.
conclusionsDispersion is a marker of neurocognitive integrity that requires further exploration in LLMD.
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