ArticleJournal of the National Cancer Institute2021
Advanced Breast Cancer Definitions by Staging System Examined in the Breast Cancer Surveillance Consortium.
Article in Journal of the National Cancer Institute, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- Advanced Versus Invasive Breast Cancer Risk in a Screening Population: Implications for Risk-based Prevention and Screening Strategies.Journal of general internal medicine · 2026Article
- A comparison of tumour characteristics of screen-detected and interval cancers and their relationship with breast density and AJCC prognostic stage in a UK screening cohort.European radiology · 2026Article
- Performance of Statistical and Machine Learning Risk Prediction Models for Advanced Breast Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2026Article
- In what clinical settings are the MASAI trial results applicable?Nature reviews. Clinical oncology · 2026Article
- Performance of breast cancer risk prediction algorithms across mammography systems in the UK screening programme.NPJ digital medicine · 2026Article
- Breast cancer risk level and prediction of tumor aggressiveness in the Athena Breast Health Network.Breast cancer research and treatment · 2026Article
- Liquid biopsy-based multi-cancer early detection: an exploration road from evidence to implementation.Science bulletin · 2025Review
- Mammographic calcifications association with risk of advanced breast cancer.Breast cancer research and treatment · 2025Article
- Vertebral Metastasis With Syringomyelia Secondary to Breast Adenocarcinoma: A Case Report and Literature Review.Clinical case reports · 2025Article
- Extending catchment area approaches to a community cancer center: a breast cancer hotspot case study.JNCI cancer spectrum · 2025Article
- Digital Breast Tomosynthesis and Digital Mammography Associated with Similar Rates of Advanced Cancer.Radiology · 2025Article
- Impact of Method of Detection of Breast Cancer on Clinical Outcomes in Individuals Aged 40 Years or Older.Radiology. Imaging cancer · 2025Observational
- Breast cancer screening needs assessment in 19 Northern California counties: geography, poverty, and racial/ethnic identity composition.Cancer causes & control : CCC · 2025Article
- Breast cancer care for the aging population: a focus on age-related disparities in breast cancer treatment.BMC cancer · 2025Article
- Observational
- Understanding mechanisms of racial disparities in breast cancer: an assessment of screening and regular care in the Carolina Breast Cancer Study.Cancer causes & control : CCC · 2024Article
- A Novel Approach for Conducting a Catchment Area Analysis of Breast Cancer by Age and Stage for a Community Cancer Center.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Response to Omoleye, Esserman, Olufunmilayo.Journal of the National Cancer Institute · 2024Article
- Trends in breast, colon, pancreatic, and uterine cancers in women during the COVID-19 pandemic in North Carolina.Cancer medicine · 2024Article
- Supplemental magnetic resonance imaging plus mammography compared with magnetic resonance imaging or mammography by extent of breast density.Journal of the National Cancer Institute · 2024Article
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Abstract
backgroundAdvanced breast cancer is an outcome used to evaluate screening effectiveness. The advanced cancer definition resulting in the best discrimination of breast cancer death has not been studied in a breast imaging population.
methodsA total of 52 496 women aged 40-79 years participating in the Breast Cancer Surveillance Consortium diagnosed with invasive cancer were staged using the 8th edition of American Joint Committee on Cancer (AJCC) anatomic and prognostic pathologic systems and Tomosynthesis Mammographic Imaging Screening Trial (TMIST) tumor categories. We calculated the area under the receiver operating characteristic curve for predicting 5-year breast cancer death and the sensitivity and specificity for predicting 5-year breast cancer death for 3 advanced cancer classifications: anatomic stage IIB or higher, prognostic pathologic stage IIA or higher, and TMIST advanced cancer.
resultsThe area under the receiver operating characteristic curves for predicting 5-year breast cancer death for AJCC anatomic stage, AJCC prognostic pathologic stage, and TMIST tumor categories were 0.826 (95% confidence interval [CI] = 0.817 to 0.835), 0.856 (95% CI = 0.846 to 0.866), and 0.789 (95% CI = 0.780 to 0.797), respectively. AJCC prognostic pathologic stage had statistically significantly better discrimination than AJCC anatomic stage (difference = 0.030, bootstrap 95% CI = 0.024 to 0.037) and TMIST tumor categories (difference = 0.067, bootstrap 95% CI = 0.059 to 0.075). The sensitivity and specificity for predicting 5-year breast cancer death for AJCC anatomic stage IIB or higher, AJCC prognostic pathologic stage IIA or higher, and TMIST advanced cancer were 72.6%, 76.7%, and 96.1%; and 78.9%, 81.6%, and 41.1%, respectively.
conclusionsDefining advanced cancer as AJCC prognostic pathologic stage IIA or higher most accurately predicts breast cancer death. Use of this definition by investigators will facilitate comparing breast cancer screening effectiveness studies.
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