ArticleeLife2020
LTD at amygdalocortical synapses as a novel mechanism for hedonic learning.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- Modulation of sweet preference by neurosteroid-sensitive, δ-GABACurrent biology : CB · 2025Article
- A neural mechanism for learning from delayed postingestive feedback.bioRxiv : the preprint server for biology · 2024Article
- Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex.Current biology : CB · 2024Article
- Glucagon-Like Peptide-1 Receptors in the Gustatory Cortex Influence Food Intake.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Experience-dependent plasticity of gustatory insular cortex circuits and taste preferences.Science advances · 2023Article
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- Epigenetic mechanisms regulate cue memory underlying discriminative behavior.Neuroscience and biobehavioral reviews · 2022Review
- Strong Aversive Conditioning Triggers a Long-Lasting Generalized Aversion.Frontiers in cellular neuroscience · 2022Article
- Brain Signaling of Indispensable Amino Acid Deficiency.Journal of clinical medicine · 2021Review
- Homeostatic synaptic scaling establishes the specificity of an associative memory.Current biology : CB · 2021Article
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- Calcineurin Participation in Hebbian and Homeostatic Plasticity Associated With Extinction.Frontiers in cellular neuroscience · 2021Review
- Review
- Cortico-amygdala interaction determines the insular cortical neurons involved in taste memory retrieval.Molecular brain · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
A novel, pleasant taste stimulus becomes aversive if associated with gastric malaise, a form of learning known as conditioned taste aversion (CTA). CTA is common to vertebrates and invertebrates and is an important survival response: eating the wrong food may be deadly. CTA depends on the gustatory portion of the insular cortex (GC) and the basolateral nucleus of the amygdala (BLA) however, its synaptic underpinnings are unknown. Here we report that CTA was associated with decreased expression of immediate early genes in rat GC of both sexes, and with reduced amplitude of BLA-GC synaptic responses, pointing to long-term depression (LTD) as a mechanism for learning. Indeed, association of a novel tastant with induction of LTD at the BLA-GC input in vivo was sufficient to change the hedonic value of a taste stimulus. Our results demonstrate a direct role for amygdalocortical LTD in taste aversion learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.