Trial reportClinical and experimental dental research2021
Early plaque formation on PTFE membranes with expanded or dense surface structures applied in the oral cavity of human volunteers.
Trial report in Clinical and experimental dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Microbial colonization in the partially exposed nonabsorbable membrane during alveolar ridge preservation.Clinical oral investigations · 2024Trial
- Early plaque formation on PTFE membranes with expanded or dense surface structures applied in the oral cavity of human volunteers.Clinical and experimental dental research · 2021Trial
- Contamination potential of non-resorbable membranes intended for exposure in the oral cavity during regenerative procedures - In vitro study.BMC oral health · 2026Article
- Biological and clinical responses to dense and expanded PTFE membranes in alveolar ridge preservation: A prospective non-randomized cohort study with ex vivo analyses.Clinical oral investigations · 2026Observational
- Recent Advances in Regenerative Therapies in Periodontology.Dentistry journal · 2025Review
- A Novel Device for the Evaluation of In Vitro Bacterial Colonization in Membranes for Guided Tissue and Bone Regeneration.Dentistry journal · 2024Article
- Differences in Mechanical and Physicochemical Properties of Several PTFE Membranes Used in Guided Bone Regeneration.Materials (Basel, Switzerland) · 2023Article
- Barrier Membranes for Guided Bone Regeneration (GBR): A Focus on Recent Advances in Collagen Membranes.International journal of molecular sciences · 2022Review
- Bacterial Growth on Three Non-Resorbable Polytetrafluoroethylene (PTFE) Membranes-An In Vitro Study.Materials (Basel, Switzerland) · 2022Article
- Advances in Modification Methods Based on Biodegradable Membranes in Guided Bone/Tissue Regeneration: A Review.Polymers · 2022Review
- The Impact of Early Saliva Interaction on Dental Implants and Biomaterials for Oral Regeneration: An Overview.International journal of molecular sciences · 2022Review
- 3D-Printed Barrier Membrane Using Mixture of Polycaprolactone and Beta-Tricalcium Phosphate for Regeneration of Rabbit Calvarial Defects.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis clinical randomized study aimed to evaluate the early plaque formation on nonresorbable polytetrafluoroethylene (PTFE) membranes having either a dense (d-PTFE) or an expanded (e-PTFE) microstructure and exposed to the oral cavity. MATERIAL AND
methodsTwelve individuals were enrolled in this study. In a split-mouth design, five test membranes (e-PTFE) with a dual-layer configuration and five control membranes (d-PTFE) were bonded on the buccal surfaces of posterior teeth of each subject. All study subjects refrained from toothbrushing during the study period. Specimens were detached from the teeth at 4 and 24 hr and subjected to viability counting, confocal microscopy, and scanning electron microscopy. Plaque samples were harvested from neighboring teeth at baseline, 4, and 24 hr, as control. Wilcoxon signed rank test was applied.
resultsNo bond failure of the membranes was reported. Between the early and late time points, viable bacterial counts increased on all membranes, with no difference between the test and control. The number of Staphylococcus spp. decreased on the tooth surfaces and increased on both membranes overtime, with a significant difference compared to teeth. The total biomass and average biofilm thickness of live and dead cells were significantly greater at the d-PTFE barriers after 4 hr.
conclusionThis study demonstrated that the e-PTFE membrane was associated with a lesser degree of biofilm accumulation during the initial exposure compared to the d-PTFE membrane. The present experimental setup provides a valuable toolbox to study the in vivo behavior of different membranes used in guided bone regeneration (GBR).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.