ArticleJournal of bioethical inquiry2020
Ethical Challenges in Clinical Research During the COVID-19 Pandemic.
Article in Journal of bioethical inquiry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A Systematic Review and Meta-analysis of the Effectiveness of Remdesivir to Treat SARS-CoV-2 in Hospitalized Patients: Have the Guidelines Evolved With the Evidence?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025Pooled it
- A rapid review of community engagement and informed consent processes for adaptive platform trials and alternative design trials for public health emergencies.Wellcome open research · 2023Pooled it
- The impact of COVID-19 on autism research: A cross-sectional analysis of discontinued or suspended clinical trials.Autism research : official journal of the International Society for Autism Research · 2022Pooled it
- Trial
- The future is now: our experience starting a remote clinical trial during the beginning of the COVID-19 pandemic.Trials · 2021Trial
- Rationale, design and baseline characteristics of a randomised controlled trial of Interventions to support Patient Activation for adults on hemoDialysis: the IPAD study protocol.BMC nephrology · 2026Article
- COVID-19 and ethics in action: Insights from African research committees.Journal of public health in Africa · 2026Article
- Research ethics and integrity challenges in accelerated clinical trials, an interview study.BMC medical ethics · 2025Article
- Article
- Burnout among surgeons before and during the SARS-CoV-2 pandemic: an international survey.BMC psychology · 2024Observational
- The readiness of the Asian research ethics committees in responding to the COVID-19 pandemic: A multi-country survey.F1000Research · 2024Article
- Clinical trials and their impact on policy during COVID-19: a review.Wellcome open research · 2024Review
- Knowledge structure and future research trends of body-mind exercise for mild cognitive impairment: a bibliometric analysis.Frontiers in neurology · 2024Article
- Overcoming recruitment hurdles in clinical trials: An investigation of remote consenting modalities and their impact on workload, workflow, and usability.Applied ergonomics · 2024Article
- The Fragility of Scientific Rigour and Integrity in "Sped up Science": Research Misconduct, Bias, and Hype and in the COVID-19 Pandemic.Journal of bioethical inquiry · 2023Article
- Challenges and solutions in clinical research during the COVID-19 pandemic: A narrative review.Health science reports · 2023Article
- Short- and long-term strategies for navigating research-ambivalent organizational cultures besetting embedded researchers.Learning health systems · 2023Article
- Ethical challenges of prospective clinical trials during the COVID-19 pandemic.Expert review of anti-infective therapy · 2022Article
- Capturing the value and core concepts of the Clinical Research Nurse.Journal of research in nursing : JRN · 2022Article
- Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The sudden emergence of the COVID-19 pandemic brought global disruption to every aspect of society including healthcare, supply chain, the economy, and social interaction. Among the many emergent considerations were the safety and public health of the public, patients, essential workers, and healthcare professionals. In certain locations, clinical research was halted-or terminated-in deference to the immediate needs of patient care, and clinical trials focusing on the treatment and prevention of coronavirus infection were prioritized over studies focusing on other diseases. Difficult decisions were made rapidly; flexibility and reconsideration were necessary not only because the intensity and severity of infection varied over time and by locale but also because knowledge of the disease and understanding of its treatment (and prevention) grew. Here we discuss the ethical challenges in decision-making and competing ethical tensions during the pandemic in an effort to advance future preparedness.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.