Evidence map›Paper›PMID 33169241›Full record

ArticleEJNMMI radiopharmacy and chemistry2020

Radioimmunotherapy of PANC-1 human pancreatic cancer xenografts in NOD/SCID or NRG mice with Panitumumab labeled with Auger electron emitting,

Sadaf Aghevlian, Zhongli Cai, David Hedley, Mitchell A Winnik, Raymond M Reilly

Open access · goldAbstract read
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. Panitumumab labeled with Auger electron-emittingEJNMMI radiopharmacy and chemistry · 2026
    Article
  2. Article
  3. Review
  4. Molecules (Basel, Switzerland) · 2022
    Article
  5. Review
  6. Dose predictions for [EJNMMI radiopharmacy and chemistry · 2021
    Article
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sadaf AghevlianDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada.
Zhongli CaiDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada.
David HedleyDepartment of Medical Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Mitchell A WinnikDepartment of Chemistry, University of Toronto, 80 St. George St, Toronto, Ontario, M5S 3H6, Canada. mwinnik@chem.utoronto.ca.ORCID https://orcid.org/0000-0002-2673-2141
Raymond M ReillyDepartment of Pharmaceutical Sciences, Leslie Dan Faculty of Pharmacy, University of Toronto, 144 College Street, Toronto, Ontario, M5S 3M2, Canada. raymond.reilly@utoronto.ca.ORCID https://orcid.org/0000-0003-1038-7993
University of Toronto · CAUniversity Health Network · CA

Funding

Canadian Cancer Society Innovation-to-Impact GrantNatural Sciences and Engineering Research Council of Canada Discovery GrantNatural Sciences and Engineering Research Council of Canada POND CREATE FellowshipProvince of Ontario Ontario Graduate ScholarshipTerry Fox Foundation STARS21 ScholarshipUniversity of Toronto CPO Scholarship
6 · The paper itself

Abstract

backgroundEpidermal growth factor receptors (EGFR) are overexpressed on > 90% of pancreatic cancers (PnCa) and represent an attractive target for the development of novel therapies, including radioimmunotherapy (RIT). Our aim was to study RIT of subcutaneous (s.c.) PANC-1 human PnCa xenografts in mice using the anti-EGFR monoclonal antibody, panitumumab labeled with Auger electron (AE)-emitting,

resultsPanitumumab was conjugated to DOTA chelators for complexing

conclusionRIT with panitumumab labeled with Auger electron-emitting,

Indexed as

111In177LuEGFRPancreatic cancerPanitumumab

Identifiers

PMID33169241
PMCPMC7652961
OpenAlexW3104946688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.