Evidence map›Paper›PMID 33168989›Full record

ArticleNature microbiology2021

Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization.

Kaitlin Schaefer, Tristan W Owens, Julia E Page, Marina Santiago, Daniel Kahne, Suzanne Walker

Open access · greenAbstract read
In one paragraph

Article in Nature microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. SpbR controls lipoteichoic acid length by directly inhibiting signal peptidase SpsB inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. The Secondary Resistome of Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2025
    Article
  9. Determinants of maturation of theJournal of bacteriology · 2024
    Article
  10. Article
  11. Chemical biology tools to probe bacterial glycans.Current opinion in chemical biology · 2024
    Review
  12. Article
  13. Journal of bacteriology · 2024
    Article
  14. Article
  15. Unveiling a CAAX Protease-Like Protein Involved in Didemnin Drug Maturation and Secretion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024
    Article
  16. Microbiology spectrum · 2023
    Article
  17. Review
  18. Identification of FacZ as a division site placement factor inbioRxiv : the preprint server for biology · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kaitlin Schaefer *Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Tristan W Owens *Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Julia E PageDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9884-2382
Marina SantiagoDepartment of Microbiology, Harvard Medical School, Boston, MA, USA.
Daniel KahneDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-8296-1424
Suzanne WalkerDepartment of Microbiology, Harvard Medical School, Boston, MA, USA. suzanne_walker@hms.harvard.edu.ORCID http://orcid.org/0000-0002-0545-914X
Harvard University · US

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Targeting bacterial cell wall biogenesis for the development of novel antimicrobU19AI109764 · NIAID · HARVARD MEDICAL SCHOOL · PI KASPER, DENNIS L. · 2014 to 2018
$25.2M
Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
Mechanism and Inhibition of Enzymes that Assemble Bacterial Cell WallR01GM076710 · NIGMS · HARVARD MEDICAL SCHOOL · PI WALKER, SUZANNE · 2007 to 2019
$5.9M
Discovery and characterization of new bacterial cell wall targets and inhibitors to treat resistant infectionsR01AI148752 · NIAID · HARVARD MEDICAL SCHOOL · PI Daniel Kahne, Suzanne Walker · 2020 to 2026
$5.5M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Understanding the Regulation and Biological Roles of Peptidoglycan Hydrolases in Staphylococcus aureusF30AI156972 · NIAID · HARVARD MEDICAL SCHOOL · PI PAGE, JULIA ELAINE · 2021 to 2023
$142k
NCRR NIH HHS S10 RR029205NIAID NIH HHS F30 AI156972NIAID NIH HHS R01 AI148752NIAID NIH HHS U19 AI109764NIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM076710NIGMS NIH HHS T32 GM007753NIH HHS S10 OD021527
6 · The paper itself

Abstract

Bacteria are encapsulated by a peptidoglycan cell wall that is essential for their survival

Indexed as

Cell MembraneCell WallHydrolasesMembrane ProteinsPeptidoglycanStaphylococcus aureusUridine Diphosphate N-Acetylmuramic AcidHydrolasesMembrane Proteinsmuramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenolPeptidoglycanUridine Diphosphate N-Acetylmuramic Acid

Identifiers

PMID33168989
PMCPMC7755832
OpenAlexW3102887030

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.