ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2021
Integration of brain and behavior measures for identification of data-driven groups cutting across children with ASD, ADHD, or OCD.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 3 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 3 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Systematic Review: Convergence and Divergence Between Autism Spectrum Disorder and Obsessive-Compulsive Disorder: Genetic, Neuroimaging, and Cognitive Findings.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Pooled it
- Repetitive Behaviors in Autism and Obsessive-Compulsive Disorder: A Systematic Review.Journal of autism and developmental disorders · 2025Pooled it
- A comprehensive review for machine learning on neuroimaging in obsessive-compulsive disorder.Frontiers in human neuroscience · 2023Pooled it
- Subtyping psychotic disorders using a data-driven approach reveals divergent cortical and cellular signatures.Molecular psychiatry · 2026Article
- From heterogeneity to translation: data‑driven subtyping of autism in a multilevel framework.Translational psychiatry · 2026Review
- Transdiagnostic behavioral and sociodemographic influences on the cognitive-adaptive functioning gap in neurodivergent children.Scientific reports · 2026Article
- Integrating Transdiagnostic and Biopsychosocial Approaches to Move Beyond Categorical Diagnoses in Neurodevelopmental Disorders: A Perspective Review.PsyCh journal · 2026Review
- Transdiagnostic Behavioral Phenotypes and Comorbid Gastrointestinal Symptoms in Neurodevelopmental Disorders: An Exploratory Study.Autism research : official journal of the International Society for Autism Research · 2026Article
- Distinct neuroimaging subtypes of ADHD among adolescents based on semi-supervised learning.Translational psychiatry · 2025Article
- Characterizing replicability in the clustering structure of brain morphology in autism, attention-deficit/hyperactivity disorder, and obsessive compulsive disorder.Translational psychiatry · 2025Article
- Brain-clinical biotyping in patients with idiopathic REM sleep behavior disorder.NPJ Parkinson's disease · 2025Article
- Neurobiology-based cognitive biotypes using multi-scale intrinsic connectivity networks in psychotic disorders.Schizophrenia (Heidelberg, Germany) · 2025Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Transdiagnostic Patterns of Sensory Processing in Autism and ADHD.Journal of autism and developmental disorders · 2024Article
- Age-Related Alterations in Gray Matter Microstructure in Older People With Remitted Major Depression at Risk for Dementia.Biological psychiatry global open science · 2024Article
- Comparing the stability and reproducibility of brain-behavior relationships found using canonical correlation analysis and partial least squares within the ABCD sample.Network neuroscience (Cambridge, Mass.) · 2024Article
- Linking functional and structural brain organisation with behaviour in autism: a multimodal EU-AIMS Longitudinal European Autism Project (LEAP) study.Molecular autism · 2023Article
- Machine learning in attention-deficit/hyperactivity disorder: new approaches toward understanding the neural mechanisms.Translational psychiatry · 2023Review
- Parsing brain-behavior heterogeneity in very preterm born children using integrated similarity networks.Translational psychiatry · 2023Article
- Comparing the stability and reproducibility of brain-behaviour relationships found using Canonical Correlation Analysis and Partial Least Squares within the ABCD Sample.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Autism spectrum disorder (ASD), obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD) are clinically and biologically heterogeneous neurodevelopmental disorders (NDDs). The objective of the present study was to integrate brain imaging and behavioral measures to identify new brain-behavior subgroups cutting across these disorders. A subset of the data from the Province of Ontario Neurodevelopmental Disorder (POND) Network was used including participants with different NDDs (aged 6-16 years) that underwent cross-sectional T1-weighted and diffusion-weighted magnetic resonance imaging (MRI) scanning on the same 3T scanner, and behavioral/cognitive assessments. Similarity Network Fusion was applied to integrate cortical thickness, subcortical volume, white matter fractional anisotropy (FA), and behavioral measures in 176 children with ASD, ADHD or OCD with complete data that passed quality control. Normalized mutual information was used to determine top contributing model features. Bootstrapping, out-of-model outcome measures and supervised machine learning were each used to examine stability and evaluate the new groups. Cortical thickness in socio-emotional and attention/executive networks and inattention symptoms comprised the top ten features driving participant similarity and differences between four transdiagnostic groups. Subcortical volumes (pallidum, nucleus accumbens, thalamus) were also different among groups, although white matter FA showed limited differences. Features driving participant similarity remained stable across resampling, and the new groups showed significantly different scores on everyday adaptive functioning. Our findings open the possibility of studying new data-driven groups that represent children with NDDs more similar to each other than others within their own diagnostic group. Future work is needed to build on this early attempt through replication of the current findings in independent samples and testing longitudinally for prognostic value.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.