Evidence map›Paper›PMID 33168861›Full record

ArticleScientific reports2020

Ceramide analog [

Simone M Crivelli, Daan van Kruining, Qian Luo, Jo A A Stevens, Caterina Giovagnoni, Andreas Paulus, Matthias Bauwens, Dusan Berkes, Helga E de Vries, Monique T Mulder and 9 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 20 citations in OpenAlex.

  1. Can Nuclear Imaging Detect Trained Immunity in Cardiovascular Disease?Arteriosclerosis, thrombosis, and vascular biology · 2026
    Review
  2. Microglial GM3 accumulation impairs Aβ phagocytic activity and promotes neuroinflammation in Alzheimer's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 5 countries.

Simone M CrivelliDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Daan van KruiningDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Qian LuoDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Jo A A StevensDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Caterina GiovagnoniDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Andreas PaulusNUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Matthias BauwensNUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Dusan BerkesDepartment of Organic Chemistry, Slovak University of Technology, Radlinského 9, 81237, Bratislava, Slovak Republic.
Helga E de VriesDepartment of Molecular Cell Biology and Immunology, Amsterdam Neuroscience, Amsterdam UMC, Amsterdam, The Netherlands.
Monique T MulderDepartment of Internal Medicine, Laboratory Vascular Medicine, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Jochen WalterDepartment of Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany.
Etienne WaelkensLaboratory of Protein Phosphorylation and Proteomics, KU Leuven, Leuven, Belgium.
Rita DeruaLaboratory of Protein Phosphorylation and Proteomics, KU Leuven, Leuven, Belgium.
Johannes V SwinnenLaboratory of Lipid Metabolism and Cancer, KU Leuven, Leuven, Belgium.
Jonas DehairsLaboratory of Lipid Metabolism and Cancer, KU Leuven, Leuven, Belgium.
Felix M MottaghyNUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, The Netherlands.
Mario LosenDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands.
Erhard BieberichDepartment of Physiology, University of Kentucky College of Medicine, Lexington, KY, USA.
Pilar Martinez-MartinezDepartment of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Universiteitssingel 50, 6229ER, Maastricht, The Netherlands. p.martinez@maastrichtuniversity.nl.
Maastricht University · NLKU Leuven · BEUniversitätsklinikum Aachen · DEVIB-KU Leuven Center for Cancer Biology · BEAmsterdam University Medical Centers · NLErasmus MC · NLMaastricht University Medical Centre · NLSlovak University of Technology in Bratislava · SKUniversity of Bonn · DEUniversity of Kentucky · US

Funding

Function of ceramide in neurodegenerative diseaseR01AG034389 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2010 to 2020
$3.6M
Regulation of Microglial Activation State by a Lipid TransporterR01AG064234 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2020 to 2024
$1.9M
Regulation of cilia by ceramideR01NS095215 · NINDS · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2016 to 2019
$1.4M
Regulation of microglial activation state in neurodegenerationR56AG064234 · NIA · UNIVERSITY OF KENTUCKY · PI BIEBERICH, ERHARD · 2019 to 2019
$375k
BLRD VA I01 BX003643NIA NIH HHS R01 AG034389NIA NIH HHS R01 AG064234NIA NIH HHS R56 AG064234NIH HHS R01AG034389NINDS NIH HHS R01 NS095215VA VA I01BX003643
6 · The paper itself

Abstract

The metabolism of ceramides is deregulated in the brain of Alzheimer's disease (AD) patients and is associated with apolipoprotein (APO) APOE4 and amyloid-β pathology. However, how the ceramide metabolism changes over time in AD, in vivo, remains unknown. Distribution and metabolism of [

Indexed as

AmidesFluorine RadioisotopesAlzheimer DiseaseAnimalsApolipoprotein E3Apolipoprotein E4AstrocytesBrainCeramidesDisease Models, AnimalFemaleHippocampusLipidomicsMass SpectrometryMiceMice, Knockout, ApoEAmidesApolipoprotein E3Apolipoprotein E4CeramidesFluorine-18Fluorine RadioisotopesN-(3-hydroxy-1-hydroxymethyl-3-phenylpropyl)dodecanamideSphingolipidsSphingomyelins

Identifiers

PMID33168861
PMCPMC7652882
OpenAlexW3105171546

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.