Evidence map›Paper›PMID 33168860›Full record

ArticleScientific reports2020

GENetic characteristics and REsponse to lipid-lowering therapy in familial hypercholesterolemia: GENRE-FH study.

Hyoeun Kim, Chan Joo Lee, Hayeon Pak, Doo-Il Kim, Moo-Yong Rhee, Byoung Kwon Lee, Youngkeun Ahn, Byung-Ryul Cho, Jeong-Taek Woo, Seung-Ho Hur and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 10 institutions in 1 country.

Hyoeun KimDepartment of Health Promotion, Yonsei University College of Medicine, Seoul, South Korea.
Chan Joo LeeDivision of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, 120-752, South Korea.
Hayeon PakDepartment of Life and Nanopharmaceutical Sciences, Graduate School, Kyung Hee University, Seoul, South Korea.
Doo-Il KimCardiology Division, Department of Internal Medicine, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Moo-Yong RheeCardiovascular Center, Dongguk University Ilsan Hospital, Goyang, South Korea.
Byoung Kwon LeeDivision of Cardiology, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Youngkeun AhnHeart Center of Chonnam National University Hospital, Gwangju, South Korea.
Byung-Ryul ChoCardiology Division, Department of Internal Medicine, Kangwon National University, School of Medicine, Chuncheon, South Korea.
Jeong-Taek WooEndocrinology Division, Department of Internal Medicine, Kyung Hee University School of Medicine, Seoul, South Korea.
Seung-Ho HurCardiology Division, Department of Internal Medicine, Keimyung University Dongsan Medical Center, Daegu, South Korea.
Jin-Ok JeongCardiology Division, Department of Internal Medicine, School of Medicine, Chungnam National University, Chungnam National University Hospital, Daejeon, South Korea.
Ji Hyun LeeDepartment of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, 26 Kyungheedae-ro, Dongdaemun-gu, Seoul, 02447, South Korea. hyunihyuni@khu.ac.kr.
Sang-Hak LeeDivision of Cardiology, Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, 134 Shinchon-dong, Seodaemun-gu, Seoul, 120-752, South Korea. shl1106@yuhs.ac.
Yonsei University · KRKyung Hee University · KRChonnam National University Hospital · KRChungnam National University Hospital · KRDongguk University Ilsan Hospital · KRInje University Haeundae Paik Hospital · KRKangwon National University · KRKeimyung University · KRKyung Hee University Medical Center · KRSeverance Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the 146 patients enrolled in the Korean FH registry, 83 patients who had undergone appropriate LLT escalation and were followed-up for ≥ 6 months were analyzed for pathogenic variants (PVs). The achieved percentage of expected low-density lipoprotein-cholesterol (LDL-C) reduction (primary variable) and achievement rates of LDL-C < 70 mg/dL were assessed. The correlations between the treatment response and the characteristics of PVs, and the weighted 4 SNP-based score were evaluated. The primary variables were significantly lower in the PV-positive patients than in the PV-negative patients (p = 0.007). However, the type of PV did not significantly correlate with the primary variable. The achievement rates of LDL-C < 70 mg/dL was very low, regardless of the PV characteristics. Patients with a higher 4-SNP score showed a lower primary variable (R

Indexed as

Polymorphism, Single NucleotideAdultAntibodies, Monoclonal, HumanizedAnticholesteremic AgentsApolipoprotein B-100AtorvastatinCholesterol, LDLFemaleGenotypeHeterozygoteHumansHyperlipoproteinemia Type IIMaleMiddle AgedProprotein Convertase 9RegistriesAntibodies, Monoclonal, HumanizedAnticholesteremic AgentsAPOB protein, humanApolipoprotein B-100AtorvastatinCholesterol, LDLevolocumabPCSK9 protein, humanProprotein Convertase 9

Identifiers

PMID33168860
PMCPMC7653043
OpenAlexW3103695120

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.