Evidence map›Paper›PMID 33168856›Full record

Observational studyScientific reports2020

Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome.

E Maziotis, K Sfakianoudis, P Giannelou, S Grigoriadis, A Rapani, P Tsioulou, K Nikolettos, A Pantou, A Tiptiri-Kourpeti, M Koutsilieris and 4 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

E MaziotisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
K SfakianoudisCentre for Human Reproduction, Genesis Athens Clinic, Athens, Greece.
P GiannelouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
S GrigoriadisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
A RapaniDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
P TsioulouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
K NikolettosAssisted Reproduction Unit of Thrace "Embryokosmogenesis", Alexandroupoli, Greece.
A PantouCentre for Human Reproduction, Genesis Athens Clinic, Athens, Greece.
A Tiptiri-KourpetiAssisted Reproduction Unit of Thrace "Embryokosmogenesis", Alexandroupoli, Greece.
M KoutsilierisDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
B AsimakopoulosDepartment of Physiology, Medical School, Democritus University of Thrace, Alexandroupoli, Greece.
N NikolettosDepartment of Physiology, Medical School, Democritus University of Thrace, Alexandroupoli, Greece.
K PantosCentre for Human Reproduction, Genesis Athens Clinic, Athens, Greece.
Mara SimopoulouDepartment of Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. marasimopoulou@hotmail.com.ORCID 0000-0002-1000-9100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A number of oocyte characteristics have been associated with fertilization, implantation and live-birth rates, albeit without reaching a consensus. This study aims to delineate possible associations between oocyte characteristics, oocyte behavior during intracytoplasmic sperm injection (ICSI), fertilization potential, and laboratory outcomes. Four-hundred and seventy-seven patients, yielding 3452 oocytes, were enrolled in this prospective observational study from 2015 to 2018. Οoplasm granularity was associated with poor embryo quality and higher probabilities of post-ICSI oocytes and embryos discarded in any developmental stage and never selected for embryo transfer or cryopreservation (p < 0.001). Both sudden or difficult ooplasm aspiration, and high or lack of resistance during ICSI were associated with either a poor Zygote-Score or fertilization failure (p < 0.001). Sudden or difficult ooplasm aspiration and high resistance during ICSI penetration were positively associated with resulting to a post-ICSI oocyte or embryo that would be selected for discard. Evaluation of oocyte characteristics and oocyte behavior during ICSI may provide early information regarding laboratory and cycle outcomes. Particularly, ooplasm granularity, and fragmentation of polar body, along with sudden or difficult ooplasm aspiration and high or lack of resistance during ICSI penetration may hinder the outcome of an ICSI cycle. The associations presented herein may contribute towards development of a grading system or a prediction model. Taking into account information on oocytes and ICSI behavior may effectively assist in enhancing IVF outcome rates.

Indexed as

AdultBirth RateCryopreservationEmbryo TransferFemaleFertilizationFertilization in VitroHumansInfertilityMaleOocytesOvulation InductionPolar BodiesPregnancyPregnancy OutcomePregnancy Rate

Identifiers

PMID33168856
PMCPMC7653966

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.