Evidence map›Paper›PMID 33168815›Full record

ArticleNature communications2020

Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury.

Mariko Hara-Chikuma, Manami Tanaka, Alan S Verkman, Masato Yasui

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
  2. Review
  3. The pathogenesis of liver fibrosis in Wilson's disease: hepatocyte injury and regulation mediated by copper metabolism dysregulation.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Current research trends of nanomedicines.Acta pharmaceutica Sinica. B · 2023
    Review
  14. Article
  15. The multifaceted role of aquaporins in physiological cell migration.American journal of physiology. Cell physiology · 2023
    Review
  16. Article
  17. Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.International journal of biological sciences · 2023
    Article
  18. Aquaporins in Immune System.Advances in experimental medicine and biology · 2023
    Article
  19. Aquaporins in Obesity.Advances in experimental medicine and biology · 2023
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mariko Hara-ChikumaDepartment of Pharmacology, School of Medicine, Keio University, Tokyo, Japan. haramari@kuhp.kyoto-u.ac.jp.ORCID 0000-0003-0593-1974
Manami TanakaDepartment of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
Alan S VerkmanDepartments of Medicine and Physiology, University of California San Francisco, San Francisco, CA, USA.
Masato YasuiDepartment of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
Keio University · JPUniversity of California, San Francisco · US

Funding

SynthesisP30DK072517 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERKMAN, ALAN S · 2005 to 2022
$18.1M
Functional Role of Aquaporins in Eye PhysiologyR01EY013574 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VERKMAN, ALAN S · 2002 to 2022
$7.6M
NEI NIH HHS R01 EY013574NIDDK NIH HHS P30 DK072517
6 · The paper itself

Abstract

Aquaporin 3 (AQP3) is a transporter of water, glycerol and hydrogen peroxide (H

Indexed as

AnimalsAntibodies, MonoclonalAquaporin 3Chemical and Drug Induced Liver InjuryChemokine CCL4CHO CellsCricetulusDisease Models, AnimalDrug DiscoveryGlycerolHydrogen PeroxideLiverMacrophagesMiceMice, Inbred C57BLMice, KnockoutAntibodies, MonoclonalAqp3 protein, mouseAquaporin 3Chemokine CCL4GlycerolHydrogen PeroxideNF-kappa B

Identifiers

PMID33168815
PMCPMC7653938
OpenAlexW3104913777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.