ArticleTranslational psychiatry2020
Educational attainment reduces the risk of suicide attempt among individuals with and without psychiatric disorders independent of cognition: a bidirectional and multivariable Mendelian randomization study with more than 815,000 participants.
Article in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Assessment of bidirectional relationships between depression and rheumatoid arthritis among adults: a two-sample Mendelian randomization study.Clinical rheumatology · 2023Pooled it
- Suicide attempt risk factors in individuals with psychiatric disorders and multi-affected families: a network analysis.Npj mental health research · 2026Article
- A phenome-wide association and Mendelian randomization study for suicide attempt within UK Biobank.Molecular psychiatry · 2026Article
- The association between the transition to parenthood and risk for nonfatal suicide attempt in a Swedish population-based sample.Psychological medicine · 2026Article
- Bidirectional associations of depression, anxiety, sleep disorders, and constipation: insights from Mendelian randomization.Archives of medical science : AMS · 2026Article
- Clinical characteristics of patients who attempt suicide by drug overdose in Western China: a retrospective analysis.BMC psychiatry · 2025Article
- Deciphering causality between social/physical activity and suicide attempt: evidence from Mendelian randomization.European archives of psychiatry and clinical neuroscience · 2025Article
- A Causal Effect of Serum 25(OH)D Level on Appendicular Muscle Mass: Evidence From NHANES Data and Mendelian Randomization Analyses.Journal of cachexia, sarcopenia and muscle · 2025Article
- Multilevel analysis of factors associated with suicide attempts: Evidence from 2022/2023 Mozambique Demographic and Health Survey.PloS one · 2025Article
- Suicidal behavior in ADHD: the role of comorbidity, psychosocial adversity, personality and genetic factors.Discover mental health · 2024Article
- Associations between polygenic liability to psychopathology and non-suicidal versus suicidal self-injury.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2024Article
- Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- The mediation effects of nightmares and depression between insomnia and suicidal ideation in young adults.Scientific reports · 2024Article
- Disparities in the prevalence of suicidal ideation according to oral contraceptive pill use among US women: A cross-sectional study.Health science reports · 2024Article
- Risk of suicidal behavior as a function of alcohol use disorder typologies: A Swedish population-based study.Addiction (Abingdon, England) · 2024Article
- Perceptions of mental health, suicide and working conditions in the construction industry-A qualitative study.PloS one · 2024Article
- Understanding the educational inequalities in suicide attempts and their mediators: a Mendelian randomisation study.General psychiatry · 2024Article
- The moderation of the genetic risk for alcohol and drug use disorders in a Swedish national sample by the genetic aptitude for educational attainment.Psychological medicine · 2023Article
- Examining the shared etiology of psychopathology with genome-wide association studies.Physiological reviews · 2023Review
- Genetic liability to suicide attempt, suicide death, and psychiatric and substance use disorders on the risk for suicide attempt and suicide death: a Swedish national study.Psychological medicine · 2023Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
Rates of suicidal behavior are increasing in the United States and identifying causal risk factors continues to be a public health priority. Observational literature has shown that educational attainment (EA) and cognitive performance (CP) influence suicide attempt risk; however, the causal nature of these relationships is unknown. Using summary statistics from genome-wide association studies (GWAS) of EA, CP, and suicide attempt risk with > 815,000 combined white participants of European ancestry, we performed multivariable Mendelian randomization (MR) to disentangle the effects of EA and CP on attempted suicide. In single-variable MR (SVMR), EA and CP appeared to reduce suicide attempt risk (EA odds ratio (OR) per standard deviation (SD) increase in EA (4.2 years), 0.524, 95% CI, 0.412-0.666, P = 1.07 × 10
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.