Evidence map›Paper›PMID 33168761›Full record

ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2020

Life expectancy and health-adjusted life expectancy in people with inflammatory bowel disease.

M Ellen Kuenzig, Douglas G Manuel, Jessy Donelle, Eric I Benchimol

Abstract read
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Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  10. The global burden of inflammatory bowel disease: from 2025 to 2045.Nature reviews. Gastroenterology & hepatology · 2025
    Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

M Ellen KuenzigDivision of Gastroenterology, Hepatology and Nutrition (Benchimol), The Hospital for Sick Children, Toronto, Ont.; Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition (Kuenzig, Benchimol: during the conduct of the study), CHEO and CHEO Research Institute; ICES uOttawa (Kuenzig, Manuel, Donelle, Benchimol); Ottawa Hospital Research Institute (Manuel, Donelle); School of Epidemiology and Public Health (Manuel, Benchimol), University of Ottawa; Department of Pediatrics (Benchimol), University of Ottawa, Ottawa, Ont.
Douglas G ManuelDivision of Gastroenterology, Hepatology and Nutrition (Benchimol), The Hospital for Sick Children, Toronto, Ont.; Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition (Kuenzig, Benchimol: during the conduct of the study), CHEO and CHEO Research Institute; ICES uOttawa (Kuenzig, Manuel, Donelle, Benchimol); Ottawa Hospital Research Institute (Manuel, Donelle); School of Epidemiology and Public Health (Manuel, Benchimol), University of Ottawa; Department of Pediatrics (Benchimol), University of Ottawa, Ottawa, Ont.
Jessy DonelleDivision of Gastroenterology, Hepatology and Nutrition (Benchimol), The Hospital for Sick Children, Toronto, Ont.; Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition (Kuenzig, Benchimol: during the conduct of the study), CHEO and CHEO Research Institute; ICES uOttawa (Kuenzig, Manuel, Donelle, Benchimol); Ottawa Hospital Research Institute (Manuel, Donelle); School of Epidemiology and Public Health (Manuel, Benchimol), University of Ottawa; Department of Pediatrics (Benchimol), University of Ottawa, Ottawa, Ont.
Eric I BenchimolDivision of Gastroenterology, Hepatology and Nutrition (Benchimol), The Hospital for Sick Children, Toronto, Ont.; Children's Hospital of Eastern Ontario (CHEO) Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition (Kuenzig, Benchimol: during the conduct of the study), CHEO and CHEO Research Institute; ICES uOttawa (Kuenzig, Manuel, Donelle, Benchimol); Ottawa Hospital Research Institute (Manuel, Donelle); School of Epidemiology and Public Health (Manuel, Benchimol), University of Ottawa; Department of Pediatrics (Benchimol), University of Ottawa, Ottawa, Ont. eric.benchimol@sickkids.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInflammatory bowel disease (IBD) may be life-threatening and often reduces quality of life. We determined trends in life expectancy and health-adjusted life expectancy in people with and without IBD.

methodsWe conducted a retrospective cohort study of population-level health administrative, demographic and health survey data available from databases in Ontario. We matched people with a diagnosis of IBD to those without a diagnosis of IBD. We used period life tables that were generated using age- and sex-specific 5-year mortality rates to calculate life expectancy (for 1996, 2000, 2008 and 2011). We incorporated the Health Utility Index (National Population Health Study; Canadian Community Health Survey) to estimate health-adjusted life expectancy (for 1996, 2000 and 2008).

resultsLife expectancy in patients with IBD increased between 1996 and 2011 (females: from 75.5 to 78.4 yr, difference: 2.9 yr [95% confidence interval (CI) 1.3 to 4.5]; males: from 72.2 to 75.5 yr, difference: 3.2 yr [95% CI 2.1 to 4.4]). Between 1996 and 2008, health-adjusted life expectancy decreased among males by 3.9 years (95% CI 1.2 to 6.6). There was no statistically significant change in health-adjusted life expectancy among females with IBD (difference: 2.0 yr, 95% CI -1.6 to 5.7). Life expectancy and health-adjusted life expectancy were lower in people with IBD compared with those without IBD. Differences in life expectancy in people with and without IBD ranged from 6.6 to 8.1 years in females and 5.0 to 6.1 years in males, depending on the year. Differences in health-adjusted life expectancy for people with and without IBD ranged from 9.5 to 13.5 years in females and 2.6 to 6.7 years in males.

interpretationWhilst life expectancy has increased among people with IBD, a gap in life expectancy between those with and without IBD remains, and the effect of pain on daily functioning contributes substantially to reduced health-adjusted life expectancy, suggesting that improved pain mitigation strategies should be implemented.

Indexed as

Life ExpectancyAdultAgedCohort StudiesFemaleHealth StatusHealth SurveysHumansInflammatory Bowel DiseasesMaleMatched-Pair AnalysisMiddle AgedOntarioPainRetrospective StudiesSex Factors

Identifiers

PMID33168761
PMCPMC7669301

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.