ArticleProceedings of the National Academy of Sciences of the United States of America2020
Insights into coral bleaching under heat stress from analysis of gene expression in a sea anemone model system.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 96 citations in OpenAlex.
- Algae-specific immune modulation influences responses to heat and pathogen challenge in a symbiotic coral.Science advances · 2026Article
- NF-κB: A Diverse and Multifunctional Transcription Factor in Holozoans.Molecular biology and evolution · 2026Review
- Metaproteome Analysis of Short-Term Thermal Stress in Three Sympatric Coral Species Reveals Divergent Host Responses.Ecology and evolution · 2026Article
- Symbiotic state affects microbiome recovery in a facultatively symbiotic cnidarian.Scientific reports · 2026Article
- Oxylipin-mediated metabolic signatures of symbiosis homeostasis and thermal stress in a model sea anemone.The ISME journal · 2026Article
- Symbiont Identity Impacts Prokaryotic Microbiome Dynamics During Heat Stress in a Model System for Corals.Integrative and comparative biology · 2026Article
- Heat Stress Drives Rapid Viral and Antiviral Innate Immunity Activation in Hexacorallia.Molecular ecology · 2025Article
- Comparative Proteomic Analysis of Non-Bleached and Bleached Fragments of the HydrocoralBiology · 2025Article
- Changes in host gene expression patterns underpin responses of the coral Stylophora pistillata to nutrient stress.Scientific reports · 2025Article
- Integrated approach to explore Anemonia viridis regeneration under a climate change scenario.Scientific reports · 2025Article
- Destabilization of mutualistic interactions shapes the early heat stress response of the coral holobiont.Microbiome · 2025Article
- Cell type-specific immune regulation under symbiosis in a facultatively symbiotic coral.The ISME journal · 2025Article
- Saving coral reefs: significance and biotechnological approaches for coral conservation.Advanced biotechnology · 2024Review
- Prior heat stress increases pathogen susceptibility in the model cnidarian Exaiptasia diaphana.Communications biology · 2024Article
- Trade-off between photosymbiosis and innate immunity influences cnidarian's response to pathogenic bacteria.Proceedings. Biological sciences · 2024Article
- Gene expression response under thermal stress in two Hawaiian corals is dominated by ploidy and genotype.Ecology and evolution · 2024Article
- Microbiome depletion and recovery in the sea anemone,mSystems · 2024Article
- Photosynthesis and other factors affecting the establishment and maintenance of cnidarian-dinoflagellate symbiosis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Multiomics data integration, limitations, and prospects to reveal the metabolic activity of the coral holobiont.FEMS microbiology ecology · 2024Review
- Starvation differentially affects gene expression, immunity and pathogen susceptibility across symbiotic states in a model cnidarian.Proceedings. Biological sciences · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Loss of endosymbiotic algae ("bleaching") under heat stress has become a major problem for reef-building corals worldwide. To identify genes that might be involved in triggering or executing bleaching, or in protecting corals from it, we used RNAseq to analyze gene-expression changes during heat stress in a coral relative, the sea anemone Aiptasia. We identified >500 genes that showed rapid and extensive up-regulation upon temperature increase. These genes fell into two clusters. In both clusters, most genes showed similar expression patterns in symbiotic and aposymbiotic anemones, suggesting that this early stress response is largely independent of the symbiosis. Cluster I was highly enriched for genes involved in innate immunity and apoptosis, and most transcript levels returned to baseline many hours before bleaching was first detected, raising doubts about their possible roles in this process. Cluster II was highly enriched for genes involved in protein folding, and most transcript levels returned more slowly to baseline, so that roles in either promoting or preventing bleaching seem plausible. Many of the genes in clusters I and II appear to be targets of the transcription factors NFκB and HSF1, respectively. We also examined the behavior of 337 genes whose much higher levels of expression in symbiotic than aposymbiotic anemones in the absence of stress suggest that they are important for the symbiosis. Unexpectedly, in many cases, these expression levels declined precipitously long before bleaching itself was evident, suggesting that loss of expression of symbiosis-supporting genes may be involved in triggering bleaching.
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