ArticleProceedings of the National Academy of Sciences of the United States of America2020
Master curve of boosted diffusion for 10 catalytic enzymes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 48 citations in OpenAlex.
- Enhanced Diffusion of Single, Lipid-Tethered Enzymes.Nano letters · 2026Article
- Preserving enzyme conformation and catalytic efficiency in crowded and active environments.Nanoscale advances · 2025Article
- Force Generation by Enhanced Diffusion in Enzyme-Loaded Vesicles.Nano letters · 2025Article
- In situ enzymatic control of colloidal phoresis and catalysis through hydrolysis of ATP.Nature communications · 2024Article
- Theoretical Improvements in Enzyme Efficiency Associated with Noisy Rate Constants and Increased Dissipation.Entropy (Basel, Switzerland) · 2024Article
- Mechanochemical active ratchet.Scientific reports · 2023Article
- Response to Comment on "Following Molecular Mobility during Chemical Reactions: No Evidence for Active Propulsion" and "Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question".Journal of the American Chemical Society · 2022Article
- Perspective: a stirring role for metabolism in cells.Molecular systems biology · 2022Review
- Displacement Statistics of Unhindered Single Molecules Show no Enhanced Diffusion in Enzymatic Reactions.Journal of the American Chemical Society · 2022Article
- Molecular Diffusivity of Click Reaction Components: The Diffusion Enhancement Question.Journal of the American Chemical Society · 2022Article
- The activity of the intrinsically water-soluble enzyme ADAMTS13 correlates with the membrane state when bound to a phospholipid bilayer.Scientific reports · 2021Article
- Nanoscale Catalyst Chemotaxis Can Drive the Assembly of Functional Pathways.The journal of physical chemistry. B · 2021Article
- Chemically-powered swimming and diffusion in the microscopic world.Nature reviews. Chemistry · 2021Review
- A thermodynamic perspective on enhanced enzyme diffusion.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular agitation more rapid than thermal Brownian motion is reported for cellular environments, motor proteins, synthetic molecular motors, enzymes, and common chemical reactions, yet that chemical activity coupled to molecular motion contrasts with generations of accumulated knowledge about diffusion at equilibrium. To test the limits of this idea, a critical testbed is the mobility of catalytically active enzymes. Sentiment is divided about the reality of enhanced enzyme diffusion, with evidence for and against. Here a master curve shows that the enzyme diffusion coefficient increases in proportion to the energy release rate-the product of Michaelis-Menten reaction rate and Gibbs free energy change (
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