ArticleProceedings of the National Academy of Sciences of the United States of America2020
Reduced thermal tolerance in a coral carrying CRISPR-induced mutations in the gene for a heat-shock transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 112 citations in OpenAlex.
- Rapid coral bleaching recovery via symbiont transfer from healthy corals.Science advances · 2026Article
- Problems With GO Enrichment as an Endpoint for Ecological Omics Interpretation.Molecular ecology · 2026Article
- Article
- Efficient genome editing using CRISPR-Cas9 in reef-building corals.Nature protocols · 2026Review
- A new era for coral functional genomics.Nature protocols · 2026Article
- A Matter of Degrees: Latitudinal Variation in the Transcriptional Response to High and Low Temperatures in an Estuarine Cnidarian.bioRxiv : the preprint server for biology · 2026Article
- Thermal Stress-Induced Alterations to Oxylipin Signal Receptors in the Cnidarian-Dinoflagellate Symbiosis.Environmental microbiology · 2026Article
- Cosmopolitan Gene Families With Known Functions Are Hotspots for the Evolution of Novel Genes in Stony Corals.Genome biology and evolution · 2026Article
- Embryonic Hormetic Priming Modulates Later-Life Thermal Tolerance.Ecology and evolution · 2026Article
- Emerging trends in genome editing of wild animals.Transgenic research · 2026Review
- Insights on the intracellular trafficking of calcifying medium in a reef-building coral.Communications biology · 2025Article
- Democratising high performance computing for bioinformatics through serverless cloud computing: A case study on CRISPR-Cas9 guide RNA design with Crackling Cloud.PLoS computational biology · 2025Article
- Controlled out-of-season spawning of reef-forming corals using offset environmental cues.Proceedings. Biological sciences · 2025Article
- Knocking out genes to reveal drivers of natural selection on phenotypic traits: a study of the fitness consequences of albinism.Proceedings. Biological sciences · 2025Article
- Future of coral bleaching research.Bioscience · 2025Article
- Transcriptomics of theEcology and evolution · 2025Article
- Living Coral Displays, Research Laboratories, and Biobanks as Important Reservoirs of Chemodiversity with Potential for Biodiscovery.Marine drugs · 2025Review
- Leveraging uncertainty quantification to optimize CRISPR guide RNA selection.Biology methods & protocols · 2025Article
- The predictability of fluctuating environments shapes the thermal tolerance of marine ectotherms and compensates narrow safety margins.Scientific reports · 2024Article
- Plant conservation in the age of genome editing: opportunities and challenges.Genome biology · 2024Review
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reef-building corals are keystone species that are threatened by anthropogenic stresses including climate change. To investigate corals' responses to stress and other aspects of their biology, numerous genomic and transcriptomic studies have been performed, generating many hypotheses about the roles of particular genes and molecular pathways. However, it has not generally been possible to test these hypotheses rigorously because of the lack of genetic tools for corals or closely related cnidarians. CRISPR technology seems likely to alleviate this problem. Indeed, we show here that microinjection of single-guide RNA/Cas9 ribonucleoprotein complexes into fertilized eggs of the coral
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.